During development, neural networks are established in a highly organized manner, which
persists throughout life. Neurotrophins play crucial roles in the developing nervous system …

Dendrite morphogenesis is a complex but well-orchestrated process and includes the
development of dendritic branches, forming characteristic dendrite arbors, and dendritic …

Autism is a neurodevelopmental disorder characterized by impairments in reciprocal social
interaction, deficits in verbal and nonverbal communication, and a restricted repertoire of …

Transient receptor potential (TRP) proteins are cation-selective channels that function in
processes as diverse as sensation and vasoregulation. Mammalian TRP channels that are …

One of the most remarkable features of the developing brain is its ability to undergo
structural change in response to experience. Among the cellular elements that show this …

Action potential propagation links information processing in different regions of the dendritic
tree. To examine the contribution of dendritic morphology to the efficacy of propagation …

The molecular mechanisms that determine the size and complexity of the neuronal dendritic
tree are unclear. Here, we show that the phosphoinositide-3′ kinase (PI3K)–Akt …

Synapse formation and stabilization in the vertebrate central nervous system is a dynamic
process, requiring bi-directional communication between pre-and postsynaptic partners …

In vivo studies indicate that synaptic activity promotes dendritic arbor elaboration at early
stages of brain development. At later stages of development, synaptic activity stabilizes …

Regulated growth and arborization of dendritic processes are critical to the formation of
functional neuronal networks. Here we identify β-catenin as a critical mediator of dendritic …