An update on microcrystalline cellulose in direct compression: Functionality, critical material attributes, and co-processed excipients
H Zhao, L Zhao, X Lin, L Shen - Carbohydrate Polymers, 2022 - Elsevier
Microcrystalline cellulose (MCC) is one of the most popular cellulose derivatives in the
pharmaceutical industry. Thanks to its outstanding tabletability, MCC is generally included in …
pharmaceutical industry. Thanks to its outstanding tabletability, MCC is generally included in …
[HTML][HTML] Meeting challenges of pediatric drug delivery: the potential of orally fast disintegrating tablets for infants and children
A majority of therapeutics are not available as suitable dosage forms for administration to
pediatric patients. The first part of this review provides an overview of clinical and …
pediatric patients. The first part of this review provides an overview of clinical and …
[HTML][HTML] Spray drying for direct compression of pharmaceuticals
Tableting by direct compression (DC) is one of the simplest and most cost-effective drug
manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and …
manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and …
Orodispersible tablets for pediatric drug delivery: current challenges and recent advances
R Wiedey, M Kokott, J Breitkreutz - Expert Opinion on Drug …, 2021 - Taylor & Francis
Introduction Child appropriate dosage forms are indispensable in modern medicine and are
a prerequisite for successful pediatric drug therapy. For years, experts have called for a …
a prerequisite for successful pediatric drug therapy. For years, experts have called for a …
Evaluation of two novel co-processed excipients for direct compression of orodispersible tablets and mini-tablets
M Kokott, A Lura, J Breitkreutz, R Wiedey - European Journal of …, 2021 - Elsevier
Pediatric, geriatric, and other patients who suffer from swallowing difficulties represent a
special patient group, where an increased need in appropriate formulation development is …
special patient group, where an increased need in appropriate formulation development is …
Formulation of Ebastine Fast‐Disintegrating Tablet Using Coprocessed Superdisintegrants and Evaluation of Quality Control Parameters
B Dhakal, JK Thakur, RK Mahato… - The Scientific World …, 2022 - Wiley Online Library
Ebastine is a long‐acting, nonsedating, second‐generation antihistaminic drug that prevents
histamine action, mainly in immediate hypersensitivity. This project was aimed to formulate …
histamine action, mainly in immediate hypersensitivity. This project was aimed to formulate …
[HTML][HTML] Orally dispersible dosage forms for paediatric use: current knowledge and development of nanostructure-based formulations
The paediatric population has always suffered from a lack of medicines tailored to their
needs, especially in terms of accurate dosage, stability and acceptability. Orodispersible …
needs, especially in terms of accurate dosage, stability and acceptability. Orodispersible …
[HTML][HTML] Scaling tableting processes from compaction simulator to rotary presses—Mind the sub-processes
I Wünsch, I Friesen, D Puckhaber, T Schlegel, JH Finke - Pharmaceutics, 2020 - mdpi.com
Compaction simulators are frequently used in the formulation and process development of
tablets, bringing about the advantages of flexibility, low material consumption, and high …
tablets, bringing about the advantages of flexibility, low material consumption, and high …
Improvements on multiple direct compaction properties of three powders prepared from Puerariae Lobatae Radix using surface and texture modification: Comparison …
Y Zhang, J Li, Y Gao, F Wu, Y Hong, L Shen… - International Journal of …, 2022 - Elsevier
It has been reported that hydrophilic nano-silica (N) markedly improved direct compaction
(DC) properties of Zingiberis Rhizoma alcoholic extract. This study aims to examine the …
(DC) properties of Zingiberis Rhizoma alcoholic extract. This study aims to examine the …
[HTML][HTML] Study of rheological and tableting properties of lubricated mixtures of co-processed dry binders for orally disintegrating tablets
T Tranová, O Macho, J Loskot, J Mužíková - European Journal of …, 2022 - Elsevier
Co-processed dry binders for ODTs are important multifunctional excipients for tablet
manufacturing by direct compression. Testing their binary mixtures with lubricants is an …
manufacturing by direct compression. Testing their binary mixtures with lubricants is an …