Emerging data suggest that ApoE affects several amyloid β-independent pathways. These
underexplored pathways may provide new insights into Alzheimer's disease pathogenesis …

Alzheimer's disease (AD) is the most common form of dementia in older adults. Currently,
there is no cure for AD. The hallmark of AD is the accumulation of extracellular amyloid …

Background Minimally invasive specific biomarkers of neurodegenerative diseases (NDs)
would facilitate patient selection and disease progression monitoring. We describe the …

Cholesterol homeostasis is a highly regulated process in human body because of its several
functions underlying the biology of cell membranes, the synthesis of all steroid hormones …

The human genome encodes a vast repertoire of protein non-coding RNAs (ncRNA), some
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …

The accumulation of lipids within drusen, the epidemiologic link of a high fat diet, and the
identification of polymorphisms in genes involved in lipid metabolism that are associated …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause of dementia. Aβ plaques and tauopathy are two major concerns associated …

Neurodegenerative diseases, namely Alzheimer's (AD), Parkinson's (PD), and Huntington's
disease (HD) together with amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) …

Gene expression is regulated at many levels, including after generation of the primary RNA
transcript from DNA but before translation into protein. Such post‐translational gene …

Background: Neuroinflammation has important effects on cognitive functions in the
pathophysiological process of Alzheimer's Disease (AD). In the current report, we …