“Stress-responsive” mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium
PH Sugden, A Clerk - Circulation research, 1998 - Am Heart Assoc
The best-characterized subfamilies of the mitogen-activated protein kinase (MAPK)
superfamily are the extracellularly responsive kinases (ERKs) and the two “stress …
superfamily are the extracellularly responsive kinases (ERKs) and the two “stress …
Cellular mechanisms of cardiac hypertrophy
PH Sugden, A Clerk - Journal of molecular medicine, 1998 - Springer
Hypertrophy of myocytes in the heart ventricles is an important adaptation that in vivo occurs
in response to a requirement for increased contractile power. It involves changes at the level …
in response to a requirement for increased contractile power. It involves changes at the level …
α1-Adrenoceptor subtypes
H Zhong, KP Minneman - European journal of pharmacology, 1999 - Elsevier
α1-Adrenoceptors are one of three subfamilies of receptors (α1, α2, β) mediating responses
to adrenaline and noradrenaline. Three α1-adrenoceptor subtypes are known (α1A, α1B …
to adrenaline and noradrenaline. Three α1-adrenoceptor subtypes are known (α1A, α1B …
[HTML][HTML] The biochemical alterations underlying post-burn hypermetabolism
C Auger, O Samadi, MG Jeschke - … Acta (BBA)-Molecular Basis of Disease, 2017 - Elsevier
A severe burn can trigger a hypermetabolic state which lasts for years following the injury, to
the detriment of the patient. The drastic increase in metabolic demands during this phase …
the detriment of the patient. The drastic increase in metabolic demands during this phase …
Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors
JS Gutkind - Science's stke, 2000 - science.org
The family of receptors that transmit signals through the activation of heterotrimeric GTP-
binding proteins (G proteins) constitutes the largest group of cell surface proteins involved in …
binding proteins (G proteins) constitutes the largest group of cell surface proteins involved in …
Mitogen-activated protein kinases: a new therapeutic target in cardiac pathology
T Ravingerová, M Barančík, M Strnisková - Molecular and Cellular …, 2003 - Springer
Eukaryotic cells respond to different external stimuli by activation of mechanisms of cell
signaling. One of the major systems participating in the transduction of signal from the cell …
signaling. One of the major systems participating in the transduction of signal from the cell …
[HTML][HTML] Role of mitogen-activated protein kinase in cardiac hypertrophy and heart failure
W Zhang, V Elimban, MS Nijjar, SK Gupta… - … & Clinical Cardiology, 2003 - ncbi.nlm.nih.gov
BACKGROUND: Mitogen-activated protein kinases (MAPKs) are involved in the regulation
of various cellular responses including cell proliferation, differentiation and survival …
of various cellular responses including cell proliferation, differentiation and survival …
Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal …
A Clerk, A MICHAEL, PH SUGDEN - Biochemical Journal, 1998 - portlandpress.com
We investigated the activation of three subfamilies of mitogen-activated protein kinases
(MAPKs), namely the stress-activated protein kinases/c-Jun N-terminal kinases …
(MAPKs), namely the stress-activated protein kinases/c-Jun N-terminal kinases …
Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes
PH Sugden, A Clerk - Antioxidants & redox signaling, 2006 - liebertpub.com
The toxic effects of oxidative stress on cells (including cardiac myocytes, the contractile cells
of the heart) are well known. However, an increasing body of evidence has suggested that …
of the heart) are well known. However, an increasing body of evidence has suggested that …
Mitogen-activated protein kinases in the heart.
The article analyzes the role of the mitogen-activated protein kinases (MAPK) in the heart.
MAPK is an important family of signal-transducing protein kinases which act by …
MAPK is an important family of signal-transducing protein kinases which act by …