Nearly all stress stimuli (eg, inflammatory cytokines, glucocorticoids, chemotherapeutics,
etc.) induce sphingolipid synthesis, leading to the accumulation of ceramides and ceramide …

Non-alcoholic fatty liver disease (NAFLD) involves a panel of pathologies starting with
hepatic steatosis and continuing to irreversible and serious conditions like steatohepatitis …

Objective—The purpose of this study was to evaluate the effect of the combined deletion of
ABCA1 and ABCG1 expression in macrophages on foam cell formation and atherosclerosis …

Niemann–Pick disease type C (NPC) is a lysosomal storage disorder characterized by liver
disease and progressive neurodegeneration. Deficiency of either NPC1 or NPC2 leads to …

Niemann‐Pick type C (NPC) disease is a fatal autosomal recessive disorder characterized
by the accumulation of free cholesterol and glycosphingolipids in the endosomal‐lysosomal …

Haloperidol, a typical antipsychotic, has been shown to inhibit cholesterol biosynthesis by
affecting Δ 7-reductase, Δ 8, 7-isomerase, and Δ 14-reductase activities, which results in the …

The genes contributing to childhood obesity are categorized into three different types based
on distinct genetic and phenotypic characteristics. These types of childhood obesity are …

Niemann‐Pick type C (NPC) disease is a neurovisceral atypical lipid storage disorder
involving the accumulation of cholesterol and other lipids in the late endocytic pathway. The …

Niemann-Pick type C1 disease (NPC1) is an autosomal recessive lysosomal storage
disorder characterized by neonatal jaundice, hepatosplenomegaly, and progressive …

Niemann–Pick type C disease is a fatal lysosomal storage disorder caused by loss of NPC1
function. The disorder severely affects multiple body systems, particularly the nervous …