The overall success of human reproduction, either spontaneously or after IVF, is highly
dependent upon maternal age. The main reasons for age-related infertility include reduced …

Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in
older women result in higher rates of miscarriage with aneuploidy. Age-related decline in …

Simple Summary A link between telomere length and some age-related diseases has been
identified, including metabolic syndrome. So far, there is no mechanism to explain the origin …

Purpose Germline mutations in BRCA genes are associated with breast and ovarian cancer
susceptibility. Because infertility is associated with breast and ovarian cancer risks, we …

The oocyte is the major determinant of embryo developmental competence in women. It
delivers half the chromosomal complement to the embryo, but the maternal and paternal …

Female fertility decreases with increasing age, a reflection of declining oocyte quantity and
quality. The menopausal transition occurs when the oocyte quantity falls below a threshold …

Ovarian age is classically considered the main cause of female reproductive infertility. In
women, the process proceeds as an ongoing decline in the primordial follicle stockpile and it …

Telomeres mediate biologic aging in organisms as diverse as plants, yeast, and mammals.
We propose a telomere theory of reproductive aging that posits telomere shortening in the …

BACKGROUND A limitation to our ability to distinguish between developmentally competent
and incompetent eggs is our still only partial knowledge of the critical features that are …

The study of mammalian meiosis is complicated by the timing of meiotic events in females
and by the intermingling of meiotic sub-stages with somatic cells in the gonad of both sexes …