Fragile X syndrome (FXS) is a common form of inherited intellectual disability and is one of
the leading known causes of autism. The mutation responsible for FXS is a large expansion …

Long-lasting forms of synaptic plasticity and memory are dependent on new protein
synthesis. Recent advances obtained from genetic, physiological, pharmacological, and …

Alzheimer's disease (AD) is the 3rd most costly disease and the leading cause of dementia.
It can linger for many years, but ultimately is fatal, the 6th leading cause of death …

Fragile X syndrome is the most common inherited form of cognitive deficiency in humans
and perhaps the best-understood single cause of autism. A trinucleotide repeat expansion …

Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that
requires protein synthesis. Here, we demonstrate that Arc/Arg3. 1 is translationally induced …

Salient stimuli that modify behavior induce transcription of activity-regulated cytoskeleton-
associated protein (Arc/Arg3. 1) and transport Arc mRNA into dendrites, suggesting that …

Fragile X is the most common known inherited cause of intellectual disability and autism,
and it typically results from transcriptional silencing of FMR1 and loss of the encoded …

Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons,
FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these …

With rapid development of sequencing technologies such as deep sequencing and whole
genome high-density tiling array, we now know that most of the “junk” genomic sequences …

The mammalian brain is plastic in the sense that it shows a remarkable capacity for change
throughout life. The contribution of neuronal activity to brain plasticity was first recognized in …