One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of
molecular biology and the new tools derived from molecular genetics have revolutionized …

Neuronal hyperexcitability produces enhanced pain transmission in the spinal dorsal horn
after spinal cord injury (SCI). Spontaneous and evoked neuronal excitability normally are …

Calcitonin gene-related peptide (CGRP), the most abundant neuropeptide in primary
afferent sensory neurons, is strongly implicated in the pathophysiology of migraine …

Primary afferent “pain” fibers (nociceptors) are divided into subclasses based on distinct
molecular and anatomical features, and these classes mediate noxious modality-specific …

Neuropathic pain is a chronic debilitating disease characterized by mechanical allodynia
and spontaneous pain. Because symptoms are often unresponsive to conventional methods …

Although transgenic and knockout mice have helped delineate the mechanisms of action of
diverse noxious compounds, it is still difficult to determine unequivocally the subpopulations …

Specific somatosensations may be processed by different subsets of primary afferents. C-
fibers expressing heat-sensitive TRPV1 channels are proposed, for example, to be heat but …

Marked hypersensitivity to heat and mechanical (pressure) stimuli develop after a burn
injury, but the neural mechanisms underlying these effects are poorly understood. In this …

The dorsal horn (DH) of the spinal cord receives a variety of sensory information arising from
the inner and outer environment, as well as modulatory inputs from supraspinal centers. This …

Tetanus toxoid (TTd) plays an important role in the pharmaceutical world, especially in
vaccines. The toxoid is obtained after formaldehyde treatment of the tetanus toxin. In …