Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …

Cholesterol is an indispensable component of the cell membrane and plays vital roles in
critical physiological processes. Brain cholesterol accounts for a large portion of total …

Abstract Background Dementia with Lewy bodies (DLB) and Parkinson's disease dementia
(PDD), which share many clinical, neurochemical, and morphological features, have been …

Dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD), although
sharing many clinical, neurochemical and morphological features, according to DSM-5, are …

Background The aggregation and spread of α-synuclein (α-Syn) protein and related
neuronal toxicity are the key pathological features of Parkinson's disease (PD) and Lewy …

Objective: A study was undertaken to examine the neuropathological substrates of cognitive
dysfunction and dementia in Parkinson disease (PD). Methods: One hundred forty patients …

People with Parkinson's disease (PD) and their care partners frequently report cognitive
decline as one of their greatest concerns. Mild cognitive impairment affects approximately 20 …

Several recent studies have shown that dementia is common in Parkinson's disease (PD),
and that in some patients, cognitive impairment occurs even at the time of diagnosis. The …

Genetic background accounts for only 5 to 10% of the reported cases of Parkinson's disease
(PD), while the remaining cases are of unknown etiology. It is believed that environmental …

Parkinson's disease (PD) is the second most common neurodegenerative illness after
Alzheimer's disease (AD). Cognitive impairment and dementia are common features in PD …