Chronic (neuro) inflammation plays an important role in many age-related central nervous
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …

The human 25-kDa Lipocalin 2 (LCN2) was first identified and purified as a protein that in
part is associated with gelatinase from neutrophils. This protein shows a high degree of …

Macrophage polarization plays essential and diverse roles in most diseases, such as
atherosclerosis, adipose tissue inflammation, and insulin resistance. Homeostasis …

Reactive astrocytes (RA) secrete lipocalin-2 (LCN2) glycoprotein that regulates diverse
cellular processes including cell death/survival, inflammation, iron delivery and cell …

Alzheimer's disease (AD) is the most common cause of dementia, affecting 35 million people
worldwide. One pathological feature of progressing AD is the loss of synapses. This is the …

Hypoxic-ischemic brain damage (HIBD) is a common cause of death or mental retardation in
newborns. Ferroptosis is a novel form of iron-dependent cell death driven by lipid …

Leukocyte migration into the central nervous system (CNS) represents a central process in
the development of neurological diseases with a detrimental inflammatory component …

Dementia accompanied by memory loss is considered one of the most common
neurodegenerative diseases worldwide, and its prevalence is gradually increasing. Known …

Background Efforts to identify fluid biomarkers of Parkinson's disease (PD) have intensified
in the last decade. As the role of inflammation in PD pathophysiology becomes increasingly …

Alzheimer's disease (AD) is a multifactorial neurodegenerative condition associated with
pathological accumulation of amyloid plaques and with the appearance of deposit of …