Following CNS injury, in an apparently counterintuitive response, scar tissue formation
inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar …

Glycosaminoglycans (GAGs) in marine animals are different to those of terrestrial organisms,
mainly in terms of molecular weight and sulfation. The therapeutic properties of GAGs are …

Glycosaminoglycans (GAGs) are complex carbohydrates that are ubiquitously present on
the cell surface and in the extracellular matrix. Interactions between GAGs and pathogens …

Glioblastoma, a malignant brain cancer, is characterized by abnormal activation of receptor
tyrosine kinase signalling pathways and a poor prognosis. Extracellular proteoglycans …

In recent years, the naturally occurring polysaccharides captured an increasing amount of
attention in the field of drug/gene delivery systems owing to their outstanding propensities …

The extracellular matrix (ECM) of the central nervous system (CNS) occupies a large part of
the neural tissue. It serves a variety of functions ranging from support of cell migration and …

Perineuronal nets (PNs) are a specialized form of brain extracellular matrix, consisting of
negatively charged glycosaminoglycans, glycoproteins and proteoglycans in the direct …

Chondroitin sulfate E (CS‐E) is a glycosaminoglycan containing type‐E disaccharide units
(sulfated at C‐4 and C‐6 of N‐acetylgalactosamine). CS‐E is covalently linked to a core …

The antiinflammatory and antiapoptotic effects of chondroitin sulfate (CS) are being used to
treat osteoarthritis. Recent evidence has revealed that those peripheral effects of CS may …

Chondroitin sulphate and heparan sulphate proteoglycans (CSPGS and HSPGs) are found
throughout the central nervous system (CNS). CSPGs are ubiquitous in the diffuse …