The bright side of the glial scar in CNS repair
A Rolls, R Shechter, M Schwartz - Nature Reviews Neuroscience, 2009 - nature.com
Following CNS injury, in an apparently counterintuitive response, scar tissue formation
inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar …
inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar …
Glycosaminoglycans from marine sources as therapeutic agents
J Valcarcel, R Novoa-Carballal, RI Pérez-Martín… - Biotechnology …, 2017 - Elsevier
Glycosaminoglycans (GAGs) in marine animals are different to those of terrestrial organisms,
mainly in terms of molecular weight and sulfation. The therapeutic properties of GAGs are …
mainly in terms of molecular weight and sulfation. The therapeutic properties of GAGs are …
Glycosaminoglycans in infectious disease
E Kamhi, EJ Joo, JS Dordick, RJ Linhardt - Biological Reviews, 2013 - Wiley Online Library
Glycosaminoglycans (GAGs) are complex carbohydrates that are ubiquitously present on
the cell surface and in the extracellular matrix. Interactions between GAGs and pathogens …
the cell surface and in the extracellular matrix. Interactions between GAGs and pathogens …
Proteoglycans and their roles in brain cancer
Glioblastoma, a malignant brain cancer, is characterized by abnormal activation of receptor
tyrosine kinase signalling pathways and a poor prognosis. Extracellular proteoglycans …
tyrosine kinase signalling pathways and a poor prognosis. Extracellular proteoglycans …
Polysaccharide-based hydrogels for medical devices, implants and tissue engineering: A review
Hydrogels are highly biocompatible biomaterials composed of crosslinked three-
dimensional networks of hydrophilic polymers. Owing to their natural origin, polysaccharide …
dimensional networks of hydrophilic polymers. Owing to their natural origin, polysaccharide …
Chondroitin sulfate-based nanocarriers for drug/gene delivery
L Zhao, M Liu, J Wang, G Zhai - Carbohydrate polymers, 2015 - Elsevier
In recent years, the naturally occurring polysaccharides captured an increasing amount of
attention in the field of drug/gene delivery systems owing to their outstanding propensities …
attention in the field of drug/gene delivery systems owing to their outstanding propensities …
Protective properties of neural extracellular matrix
A Suttkus, M Morawski, T Arendt - Molecular neurobiology, 2016 - Springer
The extracellular matrix (ECM) of the central nervous system (CNS) occupies a large part of
the neural tissue. It serves a variety of functions ranging from support of cell migration and …
the neural tissue. It serves a variety of functions ranging from support of cell migration and …
Ion exchanger in the brain: quantitative analysis of perineuronally fixed anionic binding sites suggests diffusion barriers with ion sorting properties
M Morawski, T Reinert, W Meyer-Klaucke, FE Wagner… - Scientific reports, 2015 - nature.com
Perineuronal nets (PNs) are a specialized form of brain extracellular matrix, consisting of
negatively charged glycosaminoglycans, glycoproteins and proteoglycans in the direct …
negatively charged glycosaminoglycans, glycoproteins and proteoglycans in the direct …
Proteoglycan sulphation in the function of the mature central nervous system
JW Fawcett, JCF Kwok - Frontiers in Integrative Neuroscience, 2022 - frontiersin.org
Chondroitin sulphate and heparan sulphate proteoglycans (CSPGS and HSPGs) are found
throughout the central nervous system (CNS). CSPGs are ubiquitous in the diffuse …
throughout the central nervous system (CNS). CSPGs are ubiquitous in the diffuse …
[HTML][HTML] Antioxidant, antiinflammatory and neuroprotective actions of chondroitin sulfate and proteoglycans
The antiinflammatory and antiapoptotic effects of chondroitin sulfate (CS) are being used to
treat osteoarthritis. Recent evidence has revealed that those peripheral effects of CS may …
treat osteoarthritis. Recent evidence has revealed that those peripheral effects of CS may …