Cell migration is central to a multitude of physiological processes, including embryonic
development, immune surveillance, and wound healing, and deregulated migration is key to …

The growth and migration of neurons require continuous remodelling of the neuronal
cytoskeleton, providing a versatile cellular framework for force generation and guided …

Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

The mechanical properties of substrates underlying cells can have profound effects on cell
structure and function. To examine the effect of substrate deformability on neuronal cell …

Recent studies indicate the actin and microtubule cytoskeletons are a final common target of
many signaling cascades that influence the developing neuron. Regulation of polymer …

Motile growth cones lead growing axons through developing tissues to synaptic targets.
These behaviors depend on the organization and dynamics of actin filaments that fill the …

The role of localized instability of the actin network in specifying axonal fate was examined
with the use of rat hippocampal neurons in culture. During normal neuronal development …

Axons in the CNS do not regrow after injury, whereas lesioned axons in the peripheral
nervous system (PNS) regenerate. Lesioned CNS axons form characteristic swellings at …

The myosin family of actin filament-based molecular motors consists of at least 20
structurally and functionally distinct classes. The human genome contains nearly 40 myosin …

Viruses have often been observed in association with the dense microvilli of polarized
epithelia as well as the filopodia of nonpolarized cells, yet whether interactions with these …