This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

We present a systematic analysis of epigenetic age acceleration based on by far the largest
collection of publicly available DNA methylation data for healthy samples (93 datasets, 23 K …

Opioid use disorder (OUD) is influenced by genetic and environmental factors. While recent
research suggests epigenetic disturbances in OUD, this is mostly limited to DNA methylation …

Background Opioid use disorder (OUD) affects millions of people, causing nearly 50 000
deaths annually in the United States. While opioid exposure and OUD are known to cause …

Opioid abuse during pregnancy can result in Neonatal Opioid Withdrawal Syndrome
(NOWS). We investigated genome-wide methylation analyses of 96 placental tissue …

Prenatal opioid exposure (POE) is commonly associated with neonatal opioid withdrawal
syndrome (NOWS), which is characterized by a broad variability in symptoms and severity …

Substance use disorders are highly prevalent and continue to be one of the leading causes
of disability in the world. Notably, not all people who use addictive drugs develop a …

The pharmacological management of musculoskeletal pain starts with NSAIDs, followed by
weak or strong opioids until the pain is under control. However, the treatment outcome is …

Objective Narcolepsy type 1 is a primary sleep disorder caused by deficient hypocretin
transmission leading to excessive daytime sleepiness and cataplexy. Opioids have been …

Chronic exposure to drugs of abuse produces profound changes in gene expression and
neural activity associated with drug-seeking and taking behavior. Dysregulation of opioid …