It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Somlyo, Andrew P., and Avril V. Somlyo. Ca2+ Sensitivity of Smooth Muscle and Nonmuscle
Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase. Physiol Rev 83 …

Gastrointestinal motility results from coordinated contractions of the tunica muscularis, the
muscular layers of the alimentary canal. Throughout most of the gastrointestinal tract …

Phosphorylation of myosin II plays an important role in many cell functions, including smooth
muscle contraction. The level of myosin II phosphorylation is determined by activities of …

KCl has long been used as a convenient stimulus to bypass G protein-coupled receptors
(GPCR) and activate smooth muscle by a highly reproducible and relatively “simple” …

▪ Abstract Phosphorylation of Ser19 on the 20-kDa regulatory light chain of myosin II
(MLC20) by Ca2+/calmodulin-dependent myosin light-chain kinase (MLCK) is essential for …

Objective Diverticular disease is a common complex disorder characterised by mucosal
outpouchings of the colonic wall that manifests through complications such as diverticulitis …

Seizures are often followed by sensory, cognitive or motor impairments during the postictal
phase that show striking similarity to transient hypoxic/ischemic attacks. Here we show that …

Rho-kinase (ROCK) is one of the downstream effectors of the small G-protein Rho. The Rho–
ROCK pathway has an important role in mediating various cellular functions, including …

Protein phosphatase type 1 (PP1) 1 is involved in a wide range of cell activities (1), and
even within the more restricted theme of contractile activity in muscle several processes may …