Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …

Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with
age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal …

Skeletal elements have a diverse range of shapes and sizes specialized to their various
roles including protecting internal organs, locomotion, feeding, hearing, and vocalization …

Much of the mammalian skeleton is composed of bones that originate from cartilage
templates through endochondral ossification. Elucidating the mechanisms that control …

Exposure of articular cartilage to excessive mechanical loading is deeply involved in the
pathogenesis of osteoarthritis. Here, we identify gremlin-1 as a mechanical loading …

Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

Introduction Osteoarthritis (OA) is a degenerative joint disease affecting a large population of
people. The mechanism of this highly prevalent disease is not fully understood. Currently …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Osteoarthritis (OA) is a degenerative joint disease, and the mechanism of its pathogenesis is
poorly understood. Recent human genetic association studies showed that mutations in the …

Hydrogels prepared from poly (ethylene glycol)(PEG) are widely applied in tissue
engineering, especially those derived from a combination of functional multi-arm star PEG …