Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …

Brain iron homeostasis is increasingly recognized as a potential target for the development
of drug therapies for aging‐related disorders. Dysregulation of iron metabolism associated …

The understanding of manganese (Mn) biology, in particular its cellular regulation and role
in neurological disease, is an area of expanding interest. Mn is an essential micronutrient …

Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …

Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …

Iron is a crucial transition metal for life and is the most abundant transition metal in the brain.
However, iron's biological utility as an effective redox cycling metal also endows it with the …

The brain is a singular organ of unique biological complexity that serves as the command
center for cognitive and motor function. As such, this specialized system also possesses a …

Iron is the most abundant transition metal within the brain, and is vital for a number of
cellular processes including neurotransmitter synthesis, myelination of neurons, and …

Iron is an essential element for the development and functionality of the brain, and
anomalies in its distribution and concentration in brain tissue have been found to be …

Iron is a key nutrient for normal central nervous system (CNS) development and function;
thus, iron deficiency as well as iron excess may result in harmful effects in the CNS …