ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies
AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
Research progress on the role of extracellular vesicles in neurodegenerative diseases
Z Li, X Wang, X Wang, X Yi, YK Wong, J Wu… - Translational …, 2023 - Springer
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and Huntington's disease, affect millions of people worldwide …
amyotrophic lateral sclerosis, and Huntington's disease, affect millions of people worldwide …
Targeting epigenetics: A novel promise for Alzheimer's disease treatment
D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
Molecular biomarkers and their implications for the early diagnosis of selected neurodegenerative diseases
J Doroszkiewicz, M Groblewska, B Mroczko - International Journal of …, 2022 - mdpi.com
The degeneration and dysfunction of neurons are key features of neurodegenerative
diseases (NDs). Currently, one of the main challenges facing researchers and clinicians is …
diseases (NDs). Currently, one of the main challenges facing researchers and clinicians is …
MicroRNAs; their therapeutic and biomarker properties
S Azizi Dargahlou, M Iriti, M Pouresmaeil… - Cellular, Molecular …, 2023 - cmbr-journal.com
MicroRNAs (miRNAs) are, small (roughly 19–25 nucleotides in length), conserved, non-
coding, single-stranded, and functional RNA molecules with the properties of gene …
coding, single-stranded, and functional RNA molecules with the properties of gene …
RNA-based therapeutics for neurological diseases
K Anthony - RNA biology, 2022 - Taylor & Francis
ABSTRACT RNA-based therapeutics have entered the mainstream with seemingly limitless
possibilities to treat all categories of neurological disease. Here, common RNA-based drug …
possibilities to treat all categories of neurological disease. Here, common RNA-based drug …
Microglia specific deletion of miR-155 in Alzheimer's disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures
Alzheimer's Disease (AD) is characterized by the accumulation of extracellular amyloid-β
(Aβ) as well as CNS and systemic inflammation. Microglia, the myeloid cells resident in the …
(Aβ) as well as CNS and systemic inflammation. Microglia, the myeloid cells resident in the …
[HTML][HTML] microRNA-132 regulates gene expression programs involved in microglial homeostasis
Summary microRNA-132 (miR-132), a known neuronal regulator, is one of the most robustly
downregulated microRNAs (miRNAs) in the brain of Alzheimer's disease (AD) patients …
downregulated microRNAs (miRNAs) in the brain of Alzheimer's disease (AD) patients …
Insights into role of microRNA in Alzheimer's disease: from contemporary research to bedside perspective
M Bandakinda, A Mishra - International Journal of Biological …, 2023 - Elsevier
One of the most prevalent neurodegenerative disorders is Alzheimer's disease (AD). Despite
the pervasiveness of AD being considerable, the rates of both diagnosis and therapy are …
the pervasiveness of AD being considerable, the rates of both diagnosis and therapy are …