The number of patients surviving≥ 5 years after initial cancer diagnosis has significantly
increased during the last decades due to considerable improvements in the treatment of …

Ubiquitination modulates a large repertoire of cellular functions and thus, dysregulation of
the ubiquitin system results in multiple human diseases, including cancer. Ubiquitination …

Medulloblastoma (MB) is the most common malignant childhood tumor of the brain.
Multimodal treatment consisting of surgery, radiation therapy, and chemotherapy reduced …

Endocrine complications are frequently observed in childhood cancer survivors (CCS). One
of two CCS will experience at least one endocrine complication during the course of his/her …

Exosomes are an important carrier for cell communication. miRNAs in exosomes are
potential biomarkers and therapeutic targets in different types of cancer. However, the role of …

Medulloblastoma is a malignant embryonic brain tumor arising in the posterior fossa and
typically occurring in pediatric patients. Current multimodal treatment regimes have …

Background: The lack of success of standard therapies for medulloblastoma has highlighted
the need to plan a new therapeutic approach. The purpose of this article is to provide an …

Despite great advances in understanding of molecular pathogenesis and achievement of a
high cure rate in medulloblastoma, recurrent medulloblastomas are still dismal. Additionally …

Radiotherapy is an essential element in the multidisciplinary management of children with
medulloblastoma and postoperative craniospinal axis radiotherapy is considered to be the …

Medulloblastoma is the most common form of brain malignancy of childhood. The mainstay
of epidemiological data regarding childhood medulloblastoma is derived from case series …