Prefrontal cortex as a key node in arousal circuitry

GA Mashour, D Pal, EN Brown - Trends in neurosciences, 2022 - cell.com
The role of the prefrontal cortex (PFC) in the mechanism of consciousness is a matter of
active debate. Most theoretical and empirical investigations have focused on whether the …

Prefrontal modulation of anxiety through a lens of noradrenergic signaling

NN Bouras, NR Mack, WJ Gao - Frontiers in systems neuroscience, 2023 - frontiersin.org
Anxiety disorders are the most common class of mental illness in the US, affecting 40 million
individuals annually. Anxiety is an adaptive response to a stressful or unpredictable life …

Long-term outcomes of adolescent THC exposure on translational cognitive measures in adulthood in an animal model and computational assessment of human data

JMN Ferland, RJ Ellis, G Betts, MM Silveira… - JAMA …, 2023 - jamanetwork.com
Importance Although perceived as relatively harmless and nonaddictive, adolescent
cannabis use significantly increases the likelihood of developing cannabis use disorder in …

Making and breaking habits: Revisiting the definitions and behavioral factors that influence habits in animals

SN Handel, RJ Smith - Journal of the Experimental Analysis of …, 2024 - Wiley Online Library
Habits have garnered significant interest in studies of associative learning and maladaptive
behavior. However, habit research has faced scrutiny and challenges related to the …

Prelimbic and infralimbic medial prefrontal cortex neuron activity signals cocaine seeking variables across multiple timescales

DE Moorman, G Aston-Jones - Psychopharmacology, 2023 - Springer
Abstract Rationale and Objectives The prefrontal cortex is critical for execution and inhibition
of reward seeking. Neural manipulation of rodent medial prefrontal cortex (mPFC) …

[HTML][HTML] Chemogenetic activation of prefrontal astroglia enhances recognition memory performance in rat

S Delcourte, A Bouloufa, R Rovera, C Bétry… - Biomedicine & …, 2023 - Elsevier
Prefrontal cortex (PFC) inputs to the hippocampus are supposed to be critical in memory
processes. Astrocytes are involved in several brain functions, such as homeostasis …

Optogenetic fMRI for brain-wide circuit analysis of sensory processing

JY Lee, T You, CW Woo, SG Kim - International Journal of Molecular …, 2022 - mdpi.com
Sensory processing is a complex neurological process that receives, integrates, and
responds to information from one's own body and environment, which is closely related to …

Cortico-striatal control over adaptive goal-directed responding elicited by cues signaling sucrose reward or punishment

L Hamel, B Cavdaroglu, D Yeates… - Journal of …, 2022 - Soc Neuroscience
The medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) have been associated
with the expression of adaptive and maladaptive behavior elicited by fear-related and drug …

Where actions meet outcomes: Medial prefrontal cortex, central thalamus, and the basal ganglia

RG Mair, MJ Francoeur, EM Krell… - Frontiers in Behavioral …, 2022 - frontiersin.org
Medial prefrontal cortex (mPFC) interacts with distributed networks that give rise to goal-
directed behavior through afferent and efferent connections with multiple thalamic nuclei …

The Atypical Dopamine Transporter Inhibitor CE-158 Enhances Dopamine Neurotransmission in the Prefrontal Cortex of Male Rats: A Behavioral, Electrophysiological …

C Sagheddu, E Cancedda, F Bagheri… - International Journal …, 2023 - academic.oup.com
Background Dopamine plays a key role in several physiological functions such as motor
control, learning and memory, and motivation and reward. The atypical dopamine …