B cells have a central role in many autoimmune diseases, including in those with renal
involvement, as well as in the immunological response to kidney transplantation. The …

The kynurenine pathway (KP) is highly regulated in the immune system, where it promotes
immunosuppression in response to infection or inflammation. Indoleamine 2, 3-dioxygenase …

Refractory chronic graft-versus-host disease (cGVHD) is a significant complication resulting
from allogeneic hematopoietic stem cell transplantation (HSCT). Mesenchymal stromal cells …

Whereas a B cell–transcriptional profile has been recorded for operationally tolerant kidney
graft patients, the role that B cells have in this tolerance has not been reported. In this study …

Although IL-10–producing regulatory B cells (Bregs) play important roles in immune
regulation, their surface phenotypes and functional characteristics have not been fully …

The role of Foxp3+ regulatory T cells (Tregs) in operational tolerance remains elusive, as
initial results revealed an increased frequency of this subset in tolerant patients but no …

Multiple myeloma (MM), a terminally differentiated B-cell malignancy, is characterized by
excess bone marrow (BM) plasma cells and immunosuppression. At present, the role of B …

We and others have previously described signatures of tolerance in kidney transplantation
showing the differential expression of B cell–related genes and the relative expansions of B …

B cells are typically characterized by their ability to produce antibodies, function as
secondary antigen-present cells, and produce various immunoregulatory cytokines. The …

Mouse kidney allografts are spontaneously accepted in select, fully mismatched donor-
recipient strain combinations, like DBA/2J to C57BL/6 (B6), by natural tolerance. We …