From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling
Virtual patients and digital patients/twins are two similar concepts gaining increasing
attention in health care with goals to accelerate drug development and improve patients' …
attention in health care with goals to accelerate drug development and improve patients' …
Trial watch: intratumoral immunotherapy
While chemotherapy and radiotherapy remain the first-line approaches for the management
of most unresectable tumors, immunotherapy has emerged in the past two decades as a …
of most unresectable tumors, immunotherapy has emerged in the past two decades as a …
COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes
To understand the diversity of immune responses to SARS-CoV-2 and distinguish features
that predispose individuals to severe COVID-19, we developed a mechanistic, within-host …
that predispose individuals to severe COVID-19, we developed a mechanistic, within-host …
Immunovirotherapy based on recombinant vesicular stomatitis virus: where are we?
Y Zhang, BM Nagalo - Frontiers in immunology, 2022 - frontiersin.org
Vesicular stomatitis virus (VSV), a negative-strand RNA virus of the Vesiculovirus genus, has
demonstrated encouraging anti-neoplastic activity across multiple human cancer types. VSV …
demonstrated encouraging anti-neoplastic activity across multiple human cancer types. VSV …
[HTML][HTML] Treatment of evolving cancers will require dynamic decision support
Highlights•Cancer is a heterogeneous and evolving disease, yet most drugs are
administered to simply give the maximum dose.•Treatment scheduling currently ignores the …
administered to simply give the maximum dose.•Treatment scheduling currently ignores the …
Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy
AL Jenner, M Smalley, D Goldman, WF Goins… - Iscience, 2022 - cell.com
Oncolytic viruses (OVs) are emerging cancer immunotherapy. Despite notable successes in
the treatment of some tumors, OV therapy for central nervous system cancers has failed to …
the treatment of some tumors, OV therapy for central nervous system cancers has failed to …
A practical guide for the generation of model-based virtual clinical trials
Mathematical modeling has made significant contributions to drug design, development, and
optimization. Virtual clinical trials that integrate mathematical models to explore patient …
optimization. Virtual clinical trials that integrate mathematical models to explore patient …
Assessment of clinical response to v937 oncolytic virus after intravenous or intratumoral administration using physiologically‐based modeling
ZP Parra‐Guillen, A Sancho‐Araiz… - Clinical …, 2023 - Wiley Online Library
Oncolytic viruses (OVs) represent a potential therapeutic strategy in cancer treatment.
However, there is currently a lack of comprehensive quantitative models characterizing …
However, there is currently a lack of comprehensive quantitative models characterizing …
Improving multiple-try Metropolis with local balancing
Multiple-try Metropolis (MTM) is a popular Markov chain Monte Carlo method with the
appealing feature of being amenable to parallel computing. At each iteration, it samples …
appealing feature of being amenable to parallel computing. At each iteration, it samples …
A continuation technique for maximum likelihood estimators in biological models
T Cassidy - Bulletin of Mathematical Biology, 2023 - Springer
Estimating model parameters is a crucial step in mathematical modelling and typically
involves minimizing the disagreement between model predictions and experimental data …
involves minimizing the disagreement between model predictions and experimental data …