Probing the dynamic RNA structurome and its functions
RC Spitale, D Incarnato - Nature Reviews Genetics, 2023 - nature.com
RNA is a key regulator of almost every cellular process, and the structures adopted by RNA
molecules are thought to be central to their functions. The recent fast-paced evolution of high …
molecules are thought to be central to their functions. The recent fast-paced evolution of high …
Advances and opportunities in RNA structure experimental determination and computational modeling
Beyond transferring genetic information, RNAs are molecules with diverse functions that
include catalyzing biochemical reactions and regulating gene expression. Most of these …
include catalyzing biochemical reactions and regulating gene expression. Most of these …
Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements
I Manfredonia, C Nithin… - Nucleic acids …, 2020 - academic.oup.com
SARS-CoV-2 is a betacoronavirus with a linear single-stranded, positive-sense RNA
genome, whose outbreak caused the ongoing COVID-19 pandemic. The ability of …
genome, whose outbreak caused the ongoing COVID-19 pandemic. The ability of …
The roles of structural dynamics in the cellular functions of RNAs
RNAs fold into 3D structures that range from simple helical elements to complex tertiary
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …
Revealing lncRNA structures and interactions by sequencing-based approaches
Long noncoding RNAs (lncRNAs) have emerged as significant players in almost every level
of gene function and regulation. Thus, characterizing the structures and interactions of …
of gene function and regulation. Thus, characterizing the structures and interactions of …
RNA structure probing uncovers RNA structure-dependent biological functions
RNA molecules fold into complex structures that enable their diverse functions in cells.
Recent revolutionary innovations in transcriptome-wide RNA structural probing of living cells …
Recent revolutionary innovations in transcriptome-wide RNA structural probing of living cells …
Mechanisms and regulation of RNA condensation in RNP granule formation
Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …
multiple aspects of RNA metabolism and are linked to memory, development, and disease …
RNA structure maps across mammalian cellular compartments
RNA structure is intimately connected to each step of gene expression. Recent advances
have enabled transcriptome-wide maps of RNA secondary structure, called 'RNA …
have enabled transcriptome-wide maps of RNA secondary structure, called 'RNA …
Synonymous codon substitutions perturb cotranslational protein folding in vivo and impair cell fitness
IM Walsh, MA Bowman… - Proceedings of the …, 2020 - National Acad Sciences
In the cell, proteins are synthesized from N to C terminus and begin to fold during translation.
Cotranslational folding mechanisms are therefore linked to elongation rate, which varies as …
Cotranslational folding mechanisms are therefore linked to elongation rate, which varies as …
[HTML][HTML] Ythdf m6A readers function redundantly during zebrafish development
C Kontur, M Jeong, D Cifuentes, AJ Giraldez - Cell reports, 2020 - cell.com
During the maternal-to-zygotic transition (MZT), multiple mechanisms precisely control
massive decay of maternal mRNAs. N 6-methyladenosine (m 6 A) is known to regulate …
massive decay of maternal mRNAs. N 6-methyladenosine (m 6 A) is known to regulate …