Probing the dynamic RNA structurome and its functions

RC Spitale, D Incarnato - Nature Reviews Genetics, 2023 - nature.com
RNA is a key regulator of almost every cellular process, and the structures adopted by RNA
molecules are thought to be central to their functions. The recent fast-paced evolution of high …

Advances and opportunities in RNA structure experimental determination and computational modeling

J Zhang, Y Fei, L Sun, QC Zhang - Nature methods, 2022 - nature.com
Beyond transferring genetic information, RNAs are molecules with diverse functions that
include catalyzing biochemical reactions and regulating gene expression. Most of these …

Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements

I Manfredonia, C Nithin… - Nucleic acids …, 2020 - academic.oup.com
SARS-CoV-2 is a betacoronavirus with a linear single-stranded, positive-sense RNA
genome, whose outbreak caused the ongoing COVID-19 pandemic. The ability of …

The roles of structural dynamics in the cellular functions of RNAs

LR Ganser, ML Kelly, D Herschlag… - … reviews Molecular cell …, 2019 - nature.com
RNAs fold into 3D structures that range from simple helical elements to complex tertiary
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …

Revealing lncRNA structures and interactions by sequencing-based approaches

X Qian, J Zhao, PY Yeung, QC Zhang… - Trends in biochemical …, 2019 - cell.com
Long noncoding RNAs (lncRNAs) have emerged as significant players in almost every level
of gene function and regulation. Thus, characterizing the structures and interactions of …

RNA structure probing uncovers RNA structure-dependent biological functions

XW Wang, CX Liu, LL Chen, QC Zhang - Nature chemical biology, 2021 - nature.com
RNA molecules fold into complex structures that enable their diverse functions in cells.
Recent revolutionary innovations in transcriptome-wide RNA structural probing of living cells …

Mechanisms and regulation of RNA condensation in RNP granule formation

D Tauber, G Tauber, R Parker - Trends in biochemical sciences, 2020 - cell.com
Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …

RNA structure maps across mammalian cellular compartments

L Sun, FM Fazal, P Li, JP Broughton, B Lee… - Nature structural & …, 2019 - nature.com
RNA structure is intimately connected to each step of gene expression. Recent advances
have enabled transcriptome-wide maps of RNA secondary structure, called 'RNA …

Synonymous codon substitutions perturb cotranslational protein folding in vivo and impair cell fitness

IM Walsh, MA Bowman… - Proceedings of the …, 2020 - National Acad Sciences
In the cell, proteins are synthesized from N to C terminus and begin to fold during translation.
Cotranslational folding mechanisms are therefore linked to elongation rate, which varies as …

[HTML][HTML] Ythdf m6A readers function redundantly during zebrafish development

C Kontur, M Jeong, D Cifuentes, AJ Giraldez - Cell reports, 2020 - cell.com
During the maternal-to-zygotic transition (MZT), multiple mechanisms precisely control
massive decay of maternal mRNAs. N 6-methyladenosine (m 6 A) is known to regulate …