Tuberculosis (TB) remains one of the most widespread and leading deadliest diseases,
around one-third of the world's population harbor a latent infection by Mycobacterium …

Highlights•Isocitrate lyase (ICL) is essential to growth and survival of Mycobacterium
tuberculosis (Mtb).•ICL is involved in Mtb glyoxylate and methylisocitrate cycles, and may …

The global burden of tuberculosis, its health and socio-economic impacts, the presence of
drug-resistant forms and a potential threat of latent tuberculosis should serve as a strong …

Isocitrate lyase (ICL) is the first enzyme involved in glyoxylate cycle. Many plants and
microorganisms are relying on glyoxylate cycle enzymes to survive upon downregulation of …

Buruli ulcer (BU) is caused by Mycobacterium ulcerans and is predominant in both tropical
and subtropical regions. The neglected debilitating disease is characterized by chronic …

Tuberculosis remains a global threat to public health, and dormant Mycobacterium
tuberculosis leads to long-term medication that is harmful to the human body. M …

Despite being discovered and isolated more than one hundred years ago, tuberculosis (TB)
remains a global public health concern arch. Our inability to eradicate this bacillus is …

Aim: To perform virtual screening of compounds based on natural products targeting
isocitrate lyase of Paracoccidioides brasiliensis. Materials & methods: Homology modeling …

The significant challenge in confronting TB eradication is the discursive treatment that
results in the disease reactivation, patient non compliance and drug resistance. The …

Currently used anti-tubercular drugs target actively growing Mycobacterium tuberculosis
(Mtb) but there are no current therapies targeting persistent mycobacteria. Isocitrate lyase …