Formulators are charged with the responsibility to formulate a product which is physically
and chemically stable, manufacturable, and bioavailable. Most drugs exhibit structural …

Polymorphism in molecular crystals is a prevalent phenomenon and is of great interest to the
pharmaceutical community. The solid-state form is a key quality attribute of a crystalline …

Purpose The purpose of this paper is to discuss the pharmaceutical Quality by Design (QbD)
and describe how it can be used to ensure pharmaceutical quality. Materials and Methods …

Polymorphism of drug substances has been the subject of intense investigation in the
pharmaceutical field for over 40 years. Considering the multitude of reports on solubility or …

The appearance and disappearance of polymorphs is no longer a mysterious and
inexplicable process. Although methods for polymorph control are still imperfect, there is a …

Computational chemistry applications have become an integral part of the drug discovery
workflow over the past 35 years. However, computational modeling in support of drug …

A sponsor of an Abbreviated New Drug Application (ANDA) must have information to show
that the proposed generic product and the innovator product are both pharmaceutically …

Polymorphism of rifampicin has been postulated to be responsible for its variable
bioavailability from solid oral dosage forms. In this regard, it was believed that form II is the …

Pesticides might be the only group of poisonous chemicals that are widely sprayed into the
environment, but the use of pesticides is inevitable for crop protection and infectious disease …

Tolfenamic acid (TFA) has been used until recently in prevention and treatment of diseases
with the pain and inflammation symptoms. It also showed an inhibitory activity to the growth …