Sensorineural hearing impairment is the most common sensory disorder and a major health
and socio-economic issue in industrialized countries. It is primarily due to the degeneration …

This paper will focus on understanding the role and action of reactive oxygen species (ROS)
and reactive nitrogen species (RNS) in the molecular and biochemical pathways …

Sensorineural hearing loss (SNHL), often stemming from reactive oxygen species (ROS)
generation due to various factors such as ototoxic drugs, acoustic trauma, and aging …

Gentamycin (GS) is an aminoglycoside antibiotic used to treat infections of various Gram-
negative organisms. The present study was designed to investigate the effects of GS on …

Over the past several years, advances in our understanding of the pathogenesis of acute
kidney injury (AKI) have demonstrated the role of oxidant stress and reactive oxygen …

Since introduction into clinical practice over 60 years ago, aminoglycoside antibiotics remain
important drugs in the treatment of bacterial infections, cystic fibrosis and tuberculosis …

Following the efforts of patient advocates, the World Health Organization published updated
guidelines for management of multidrug-resistant tuberculosis in 2018 that advised against …

Individuals treated for multidrug-resistant tuberculosis (MDR-TB) with aminoglycosides
(AGs) in resource-limited settings often experience permanent hearing loss. However, AG …

Objective To investigate the potential protective effect of thymoquinone in gentamicin-
induced ototoxicity through auditory brain stem responses (ABR) testing and …

Aminoglycosides are broad-spectrum antibiotics that are used for the treatment of severe
Gram-negative and Gram-positive bacterial infections. While bactericidal effects of …