Leptin, a hormone that is capable of effectively reducing food intake and body weight, was
initially considered for use in the treatment of obesity. However, obese subjects have since …

The adipocyte-derived adipokine leptin exerts pleiotropic effects, which are essential for the
regulation of energy balance and cell metabolism, for controlling inflammatory and immune …

Hormone-secreting cells within pancreatic islets of Langerhans play important roles in
metabolic homeostasis and disease. However, their transcriptional characterization is still …

Under normal physiological conditions, leptin and the leptin receptor (ObR) regulate the
body weight by balancing food intake and energy expenditure. However, this adipocyte …

We summarize the biological impact of leptin signaling as well as the molecular and cellular
characteristics of leptin action. Our focus is principally in the central nervous system and we …

Obesity is strongly related to leptin resistance that refers to the state in which leptin fails to
inhibit appetite, enhance energy expenditure and regulate glycolipid metabolism, whereas …

Introduction: Obesity is a body weight disorder characterized by excess adiposity that
increases the risk for developing co-morbidities such as type 2 diabetes. A large medical …

As we approach the end of two decades of leptin research, the comparative biology of leptin
is just beginning. We now have several leptin orthologs described from nearly every major …

Over a decade passed between Friedman's discovery of the mammalian leptin gene and its
cloning in fish and amphibians. Since 2005, the concept of gene synteny conservation (vs …

The regulation of organ size is essential to human health and has fascinated biologists for
centuries. Key to the growth process is the ability of most organs to integrate organ-extrinsic …