Mouse cortical organoids reveal key functions of p73 isoforms: TAp73 governs the establishment of the archetypical ventricular-like zones while DNp73 is central in …

H Alonso-Olivares, MM Marques… - Frontiers in Cell and …, 2024 - frontiersin.org
Introduction Neurogenesis is tightly regulated in space and time, ensuring the correct
development and organization of the central nervous system. Critical regulators of brain …

Using deep learning to decipher the impact of telomerase promoter mutations on the dynamic metastatic morpholome

AJ Nevarez, A Mudla, SA Diaz… - PLOS Computational …, 2024 - journals.plos.org
Melanoma showcases a complex interplay of genetic alterations and intra-and inter-cellular
morphological changes during metastatic transformation. While pivotal, the role of specific …

Actomyosin Contractility is a Potent Suppressor of Mesoderm Induction by Human Pluripotent Stem Cells

L Fort, W Wang, I Macara - bioRxiv, 2024 - biorxiv.org
The activation of WNT signaling in human pluripotent stem cells drives efficient conversion
to lateral mesoderm, which can be further differentiated into cardiomyocytes. Stabilization of …

[PDF][PDF] REGULATORY ROLE OF ETV4 IN EMBRYONIC STEM CELL FATE: INSIGHTS INTO MECHANOTRANSDUCTION AND LINEAGE DETERMINATION

A Ardiana - Journal of SCRTE, 2024 - e-journal.unair.ac.id
Conventional cell biology studies focus on cellular responses to chemical signals, but cells
also react to mechanical cues like density, size, and substrate rigidity, activating specific …