Radiotherapy toxicity

D De Ruysscher, G Niedermann, NG Burnet… - Nature Reviews …, 2019 - nature.com
Radiotherapy is used in> 50% of patients with cancer, both for curative and palliative
purposes. Radiotherapy uses ionizing radiation to target and kill tumour tissue, but normal …

Clinical translation of FLASH radiotherapy: Why and how?

J Bourhis, P Montay-Gruel, PG Jorge, C Bailat… - Radiotherapy and …, 2019 - Elsevier
Over the past decades, technological advances have transformed radiation therapy (RT) into
a precise and powerful treatment for cancer patients. Nevertheless, the treatment of radiation …

Treatment of a first patient with FLASH-radiotherapy

J Bourhis, WJ Sozzi, PG Jorge, O Gaide, C Bailat… - Radiotherapy and …, 2019 - Elsevier
Background When compared to conventional radiotherapy (RT) in pre-clinical studies,
FLASH-RT was shown to reproducibly spare normal tissues, while preserving the anti-tumor …

[HTML][HTML] Radiation-induced lung injury (RILI)

L Giuranno, J Ient, D De Ruysscher, MA Vooijs - Frontiers in oncology, 2019 - frontiersin.org
Radiation pneumonitis (RP) and radiation fibrosis (RF) are two dose-limiting toxicities of
radiotherapy (RT), especially for lung, and esophageal cancer. It occurs in 5–20% of …

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

V Favaudon, L Caplier, V Monceau… - Science translational …, 2014 - science.org
In vitro studies suggested that sub-millisecond pulses of radiation elicit less genomic
instability than continuous, protracted irradiation at the same total dose. To determine the …

[HTML][HTML] 2nd ESMO Consensus Conference in Lung Cancer: locally advanced stage III non-small-cell lung cancer

WEE Eberhardt, D De Ruysscher, W Weder… - Annals of …, 2015 - Elsevier
To complement the existing treatment guidelines for all tumour types, ESMO organises
consensus conferences to focus on specific issues in each type of tumour. The 2nd ESMO …

Imaging-based target volume reduction in chemoradiotherapy for locally advanced non-small-cell lung cancer (PET-Plan): a multicentre, open-label, randomised …

U Nestle, T Schimek-Jasch, S Kremp… - The Lancet …, 2020 - thelancet.com
Background With increasingly precise radiotherapy and advanced medical imaging, the
concept of radiotherapy target volume planning might be redefined with the aim of improving …

[HTML][HTML] Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

J Vansteenkiste, D De Ruysscher… - Annals of …, 2013 - annalsofoncology.org
A high proportion of NSCLC patients present with symptoms in advanced disease stage.
The aim of lung cancer screening is to reduce lung cancer-related mortality by detecting …

[HTML][HTML] Radiation-induced lung toxicity–cellular and molecular mechanisms of pathogenesis, management, and literature review

L Käsmann, A Dietrich, CA Staab-Weijnitz… - Radiation …, 2020 - Springer
Lung, breast, and esophageal cancer represent three common malignancies with high
incidence and mortality worldwide. The management of these tumors critically relies on …

Safety evaluation of nivolumab added concurrently to radiotherapy in a standard first line chemo-radiotherapy regimen in stage III non-small cell lung cancer—The …

S Peters, E Felip, U Dafni, C Belka, M Guckenberger… - Lung cancer, 2019 - Elsevier
Objectives Chemo-radiotherapy (CRT) and concurrent PD-1 inhibition has shown promising
results in pre-clinical models. So far, the feasibility of delivering concurrent CRT and PD …