Biological materials: the next frontier for cell-free synthetic biology

RJR Kelwick, AJ Webb, PS Freemont - Frontiers in Bioengineering …, 2020 - frontiersin.org
Advancements in cell-free synthetic biology are enabling innovations in sustainable
biomanufacturing, that may ultimately shift the global manufacturing paradigm toward …

Promoting microbiology education through the iGEM synthetic biology competition

R Kelwick, L Bowater, KH Yeoman… - FEMS microbiology …, 2015 - academic.oup.com
Synthetic biology has developed rapidly in the 21st century. It covers a range of scientific
disciplines that incorporate principles from engineering to take advantage of and improve …

Polyhydroxyalkanoates Production: A Challenge for the Plastic Industry

F Guzmán-Lagunes, P Wongsirichot… - Industrial & …, 2023 - ACS Publications
The accumulation of petroleum-based plastics in the environment has heightened the
necessity of finding alternative materials with similar properties and lower environmental …

Precise flux redistribution to glyoxylate cycle for 5-aminolevulinic acid production in Escherichia coli

MH Noh, HG Lim, S Park, SW Seo, GY Jung - Metabolic Engineering, 2017 - Elsevier
Microbial production of 5-aminolevulinic acid (ALA) has received much attention because of
its potential in clinical applications. Overexpression along with the deciphering of regulation …

Cell-free prototyping strategies for enhancing the sustainable production of polyhydroxyalkanoates bioplastics

R Kelwick, L Ricci, SM Chee, D Bell, AJ Webb… - Synthetic …, 2018 - academic.oup.com
The polyhydroxyalkanoates (PHAs) are microbially-produced biopolymers that could
potentially be used as sustainable alternatives to oil-derived plastics. However, PHAs are …

Comprehensive study of microbial bioplastic: present status and future perspectives for sustainable development

DD Kapoor, S Yadav, RK Gupta - Environment, Development and …, 2024 - Springer
Increasing human population demands more usage of consumable items thus causes more
destruction to the environment by developing advanced materials and technologies …

[HTML][HTML] AL-PHA beads: Bioplastic-based protease biosensors for global health applications

RJR Kelwick, AJ Webb, Y Wang, A Heliot, F Allan… - Materials Today, 2021 - Elsevier
Proteases are multi-functional proteolytic enzymes that have complex roles in human health
and disease. Therefore, the development of protease biosensors can be beneficial to global …

Auxotrophic selection strategy for improved production of coenzyme B12 in Escherichia coli

MH Noh, HG Lim, D Moon, S Park, GY Jung - Iscience, 2020 - cell.com
The production of coenzyme B 12 using well-characterized microorganisms, such as
Escherichia coli, has recently attracted considerable attention to meet growing demands of …

Systematic investigation of synthetic operon designs enables prediction and control of expression levels of multiple proteins

D Gerngross, N Beerenwinkel, S Panke - bioRxiv, 2022 - biorxiv.org
Controlling the expression levels of multiple recombinant proteins for optimal performance is
crucial for synthetic biosystems but remains difficult given the large number of DNA-encoded …

Method for isolating extracellular vesicles

R Kelwick Jr - US Patent App. 17/762,931, 2022 - Google Patents
The present invention provides a gentle and low cost means to isolate extracellular vesicles,
including exosomes, from a surrounding sample. In particular the invention relates to the use …