Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma
W Luo, J Hu, W Xu, J Dong - Frontiers in Immunology, 2022 - frontiersin.org
Immune response in the asthmatic respiratory tract is mainly driven by CD4+ T helper (Th)
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …
The ins and outs of innate and adaptive type 2 immunity
AB Molofsky, RM Locksley - Immunity, 2023 - cell.com
Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …
SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147
S Shouman, N El-Kholy, AE Hussien… - Cell Communication and …, 2024 - Springer
T lymphocytes play a primary role in the adaptive antiviral immunity. Both lymphocytosis and
lymphopenia were found to be associated with severe acute respiratory syndrome …
lymphopenia were found to be associated with severe acute respiratory syndrome …
Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation
G Scarno, J Mazej, M Laffranchi… - Proceedings of the …, 2023 - National Acad Sciences
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1) require signal transducer
and activator of transcription 4 (STAT4) to elicit rapid effector responses and protect against …
and activator of transcription 4 (STAT4) to elicit rapid effector responses and protect against …
The unique role of innate lymphoid cells in cancer and the hepatic microenvironment
Cancer is a complex disease, and despite incredible progress over the last decade, it
remains the leading cause of death worldwide. Liver cancers, including hepatocellular …
remains the leading cause of death worldwide. Liver cancers, including hepatocellular …
Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior
The innate immune system shapes brain development and is implicated in
neurodevelopmental diseases. It is critical to define the relevant immune cells and signals …
neurodevelopmental diseases. It is critical to define the relevant immune cells and signals …
Differential regulation of lineage-determining transcription factor expression in innate lymphoid cell and adaptive T helper cell subsets
CD4 T helper (Th) cell subsets, including Th1, Th2 and Th17 cells, and their innate
counterparts innate lymphoid cell (ILC) subsets consisting of ILC1s, ILC2s and ILC3s …
counterparts innate lymphoid cell (ILC) subsets consisting of ILC1s, ILC2s and ILC3s …
Tissue resident and migratory group 2 innate lymphoid cells
Group 2 innate lymphoid cells (ILC2s) are present in both mouse and human mucosal and
non-mucosal tissues and implicated in initiating type 2 inflammation. ILC2s are considered …
non-mucosal tissues and implicated in initiating type 2 inflammation. ILC2s are considered …
The modulation of pulmonary group 2 innate lymphoid cell function in asthma: from inflammatory mediators to environmental and metabolic factors
CLP Thio, YJ Chang - Experimental & Molecular Medicine, 2023 - nature.com
A dysregulated type 2 immune response is one of the fundamental causes of allergic
asthma. Although Th2 cells are undoubtedly central to the pathogenesis of allergic asthma …
asthma. Although Th2 cells are undoubtedly central to the pathogenesis of allergic asthma …