Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Background The global rise of metabolic disorders, such as obesity, type 2 diabetes, and
cardiovascular disease, demands a thorough molecular understanding of the cellular …

The central nervous system (CNS) receives information from afferent neurons, circulating
hormones, and absorbed nutrients and integrates this information to orchestrate the actions …

Mitochondria sense and respond to many stressors and can support cell survival or death
through energy production and signalling pathways. Mitochondrial responses depend on …

Energy is required to sustain life and enable stress adaptation. At the cellular level, energy is
largely derived from mitochondria–unique multifunctional organelles with their own genome …

Mitochondrial morphology varies tremendously across cell types and tissues, changing
rapidly in response to external insults and metabolic cues, such as nutrient status. The many …

The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures,
as they intimately communicate, forming very dynamic platforms termed mitochondria …

Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …