Abstract The actin-related protein 2/3 (ARP2/3) complex nucleates branched actin filament
networks, but requires nucleation promoting factors (NPFs) to stimulate this activity. NPFs …

For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-
promoting factors and formins were the only molecules known to directly nucleate actin …

Wiskott‐Aldrich syndrome (WAS) is a rare X‐linked primary immunodeficiency characterized
by microthrombocytopenia, eczema, recurrent infections, and an increased incidence of …

The Arp2/3 complex generates branched actin networks when activated by Nucleation
Promoting Factors (NPFs). Recently, the WASH family of NPFs has been identified, but its …

The Arp2/3 complex regulates endocytosis, sorting, and trafficking, yet the Arp2/3-stimulating
factors orchestrating these distinct events remain ill defined. WASH (Wiskott-Aldrich …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

ABSTRACT Proteins of the Wiskott–Aldrich syndrome protein (WASP) family function as
nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives …

Genome sequences of diverse free-living protists are essential for understanding eukaryotic
evolution and molecular and cell biology. The free-living amoeboflagellate Naegleria …

The WAVE regulatory complex (WRC) controls actin cytoskeletal dynamics throughout the
cell by stimulating the actin-nucleating activity of the Arp2/3 complex at distinct membrane …

The tubular endolysosomal network is a quality control system that ensures the proper
delivery of internalized receptors to specific subcellular destinations in order to maintain …