Sertoli cells are the orchestrators of spermatogenesis; they support fetal germ cell
commitment to the male pathway and are essential for germ cell development, from …

Maternal and paternal factors influence offspring development and program its genome for
successful postnatal life. Based on the stressors during gestation, the pregnant female …

Male reproductive health has declined as indicated by increasing rates of cryptorchidism, ie,
undescended testis, poor semen quality, low serum testosterone level, and testicular cancer …

Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone.
ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs) …

Organogenesis of the ovary is a highly orchestrated process involving multiple lineage
determination of ovarian surface epithelium, granulosa cells and theca cells. Although the …

Background Testicular architecture and sperm production are supported by a complex
network of communication between various cell types. These signals ensure fertility by …

Steroid hormones regulate essential physiological processes and inadequate levels are
associated with various pathological conditions. Consequently, the process of steroid …

The reproductive endocrine systems are vastly different between males and females. This
sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the …

Semen quality has been suggested to be a biological marker of long-term morbidity and
mortality; however, few studies have been conducted on this subject. We identified 5,370 …

Testosterone is essential for spermatogenesis and male fertility. In this review, topics related
to testosterone control of spermatogenesis are covered including testosterone production …