Protein lipidation in health and disease: molecular basis, physiological function and pathological implication

Y Yuan, P Li, J Li, Q Zhao, Y Chang, X He - Signal Transduction and …, 2024 - nature.com
Posttranslational modifications increase the complexity and functional diversity of proteins in
response to complex external stimuli and internal changes. Among these, protein lipidations …

Membrane trafficking alterations in breast cancer progression

A Ferreira, P Castanheira, C Escrevente… - Frontiers in Cell and …, 2024 - frontiersin.org
Breast cancer (BC) is the most common type of cancer in women, and remains one of the
major causes of death in women worldwide. It is now well established that alterations in …

Refining S-acylation: Structure, regulation, dynamics, and therapeutic implications

MU Anwar, FG van der Goot - Journal of Cell Biology, 2023 - rupress.org
With a limited number of genes, cells achieve remarkable diversity. This is to a large extent
achieved by chemical posttranslational modifications of proteins. Amongst these are the lipid …

Defining the cell surface cysteinome using two-step enrichment proteomics

T Yan, LM Boatner, L Cui, PJ Tontonoz, KM Backus - JACS Au, 2023 - ACS Publications
The plasma membrane proteome is a rich resource of functionally important and
therapeutically relevant protein targets. Distinguished by high hydrophobicity, heavy …

Non-alcoholic fatty liver disease promotes liver metastasis of colorectal cancer via fatty acid synthase dependent EGFR palmitoylation

C Zhang, Y Zhang, Y Dong, R Zi, Y Wang, Y Chen… - Cell Death …, 2024 - nature.com
Liver metastasis is the major reason for most of colorectal cancer (CRC) related deaths.
Accumulating evidence indicates that CRC patients with non-alcoholic fatty liver disease …

ARF6 plays a general role in targeting palmitoylated proteins from the Golgi to the plasma membrane

J Wang, LF Zheng, S Ren, DL Li, C Chen… - Journal of Cell …, 2023 - journals.biologists.com
Protein palmitoylation is a post-translational lipid modification of proteins. Accumulating
evidence reveals that palmitoylation functions as a sorting signal to direct proteins to …

Overexpression of RAB27A in oral squamous cell carcinoma promotes tumor migration and invasion via modulation of EGFR membrane stability

J Huang, JG Yang, JG Ren, HF Xia, GH Chen… - International Journal of …, 2023 - mdpi.com
Oral squamous cell carcinoma (OSCC) is the most prevalent subtype of head and neck
tumors, highly prone to lymph node metastasis. This study aims to examine the expression …

Arf6 is required for endocytosis and filamentous actin assembly during angiogenesis in vitro

CR Francis, ML Bell, MM Skripnichuk… - …, 2023 - Wiley Online Library
Objective Endocytosis is a process vital to angiogenesis and vascular homeostasis. In
pathologies where supraphysiological growth factor signaling underlies disease etiology …

Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration

J Wang, DL Li, LF Zheng, S Ren, ZQ Huang, Y Tao… - Developmental Cell, 2024 - cell.com
Different types of cells uptake fatty acids in response to different stimuli or physiological
conditions; however, little is known about context-specific regulation of fatty acid uptake …

A glimpse into novel acylations and their emerging role in regulating cancer metastasis

H Shi, W Cui, Y Qin, L Chen, T Yu, J Lv - Cellular and Molecular Life …, 2024 - Springer
Metastatic cancer is a major cause of cancer-related mortality; however, the complex
regulation process remains to be further elucidated. A large amount of preliminary …