Uric acid is synthesized mainly in the liver, intestines and the vascular endothelium as the
end product of an exogenous pool of purines, and endogenously from damaged, dying and …

Uric acid is the end product of purine metabolism in humans, and its excessive accumulation
leads to hyperuricemia and urate crystal deposition in tissues including joints and kidneys …

Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia that leads to numerous adverse
outcomes including stroke, heart failure, and death. Hyperuricemia is an important risk factor …

Urate crystals activate innate immunity through Toll like receptor 4 (TLR4) activation, leading
to the formation of the NACHT, LRR and PYD domains-containing protein 3 [NALP3; also …

Hyperuricaemia is a disorder of purine metabolism, and is strongly associated with insulin
resistance and abnormal glucose metabolism. As the producer of insulin, pancreatic β cells …

Background Uric acid has emerged as a novel and potential modifiable risk factor for the
incidence and progression of kidney diseases, however, the deteriorate effect of uric acid on …

Background/Aims: Hyperuricemia is part of the metabolic-syndrome cluster of abdominal
obesity, impaired glucose tolerance, insulin resistance, dyslipidemia, and hypertension …

Hyperuricemia, defined as the presence of elevated serum uric acid (sUA), could lead to
urate deposit in joints, tendons, kidney and other tissues. Hyperuricemia as an independent …

Hyperuricosuria is associated with kidney stone disease, especially uric acid (UA) and
calcium oxalate (CaOx) types. Nevertheless, detailed mechanisms of hyperuricosuria …

Uric acid crystal is known to activate the NLRP3 inflammasome and to cause tissue
damages, which can result in many diseases, such as gout, chronic renal injury and …