Epigenetic control of gene expression: Potential implications for cancer treatment

F Perri, F Longo, M Giuliano, F Sabbatino… - Critical reviews in …, 2017 - Elsevier
Epigenetic changes are defined as inherited modifications that are not present in DNA
sequence. Gene expression is regulated at various levels and not only in response to DNA …

Emerging role of MiR-192-5p in human diseases

F Ren, Y Yao, X Cai, G Fang - Frontiers in Pharmacology, 2021 - frontiersin.org
MicroRNAs (miRNAs) are a type of small non-coding RNAs that play an essential role in
numerous biological processes by regulating the post-transcriptional expression of target …

Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice

S Tanaka, H Hikita, T Tatsumi, R Sakamori, Y Nozaki… - Hepatology, 2016 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. It
encompasses a spectrum ranging from simple steatosis to fatty liver with hepatocellular …

Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma

XY Huang, ZL Huang, YH Xu, Q Zheng, Z Chen… - Scientific reports, 2017 - nature.com
Circular RNAs (circRNAs) represent a class of endogenous noncoding RNAs that have
recently been recognized as important regulators of gene expression and pathological …

Exosomal miRNA confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in ovarian cancer

P Kanlikilicer, R Bayraktar, M Denizli, MH Rashed… - …, 2018 - thelancet.com
Background Circulating miRNAs are known to play important roles in intercellular
communication. However, the effects of exosomal miRNAs on cells are not fully understood …

[PDF][PDF] Octamer 4/microRNA‐1246 signaling axis drives Wnt/β‐catenin activation in liver cancer stem cells

S Chai, KY Ng, M Tong, EY Lau, TK Lee, KW Chan… - …, 2016 - Wiley Online Library
Wnt/β‐catenin signaling is activated in CD133 liver cancer stem cells (CSCs), a subset of
cells known to be a root of tumor recurrence and therapy resistance in hepatocellular …

Circulating extracellular vesicle microRNA as diagnostic biomarkers in early colorectal cancer—A review

BJ Desmond, ER Dennett, KM Danielson - Cancers, 2019 - mdpi.com
Colorectal cancer (CRC) is one of the most common malignancies in the developed world,
with global deaths expected to double in the next decade. Disease stage at diagnosis is the …

MicroRNA expression analysis in high fat diet-induced NAFLD-NASH-HCC progression: study on C57BL/6J mice

A Tessitore, G Cicciarelli, F Del Vecchio, A Gaggiano… - BMC cancer, 2016 - Springer
Background Hepatocellular carcinoma (HCC) is the most common malignant tumor of the
liver. Non-alcoholic fatty liver disease (NAFLD) is a frequent chronic liver disorder in …

Oncogenic miRNAs and target therapies in colorectal cancer

A Saberinia, A Alinezhad, F Jafari, S Soltany… - Clinica Chimica …, 2020 - Elsevier
OncomiRNAs involved in human colorectal cancer (CRC) are capable of suppressing the
expression of their targets via cleavage or translational arrest. Therefore, an improved …

MicroRNA-1246 promotes growth and metastasis of colorectal cancer cells involving CCNG2 reduction

S Wang, Y Zeng, JM Zhou, SL Nie… - Molecular …, 2016 - spandidos-publications.com
Colorectal cancer (CRC) is the third most common cancer type and the fourth leading cause
of cancer-associated mortality worldwide. MicroRNA (miR)-1246 is involved in …