Cell-Based Covalent-Capture Deubiquitinase Assay for Inhibitor Discovery
MN Doleschal, J Miller, S Jain… - ACS Pharmacology & …, 2024 - ACS Publications
Ubiquitination is a post-translational modification that elicits a variety of cellular responses.
Deubiquitinases (DUBs) remove ubiquitin moieties from proteins and modulate cellular …
Deubiquitinases (DUBs) remove ubiquitin moieties from proteins and modulate cellular …
In-cell bioluminescence resonance energy transfer (BRET)-based assay uncovers ceritinib and CA-074 as SARS-CoV-2 papain-like protease inhibitors
M Li, ZC Bei, Y Yuan, B Wang, D Zhang… - Journal of Enzyme …, 2024 - Taylor & Francis
Papain-like protease (PLpro) is an attractive anti-coronavirus target. The development of
PLpro inhibitors, however, is hampered by the limitations of the existing PLpro assay and the …
PLpro inhibitors, however, is hampered by the limitations of the existing PLpro assay and the …