Mechanotransduction is a fundamental ability that allows living organisms to receive and
respond to physical signals from both the external and internal environments. The …

Cellular mechanotransduction, the process of translating mechanical forces into biological
signals, is crucial for a wide range of physiological processes. A role for ion channels in …

The mechanosensitive Piezo channels function as key eukaryotic mechanotransducers.
However, their structures and mechanogating mechanisms remain unknown. Here we …

Mechanosensitive ion channels convert external mechanical stimuli into electrochemical
signals for critical processes including touch sensation, balance, and cardiovascular …

The pathology of Alzheimer's disease (AD) is featured with extracellular amyloid-β (Aβ)
plaques, whose impact on the mechanical properties of the surrounding brain tissues is …

Mechanosensitive ion channels are force-transducing enzymes that couple mechanical
stimuli to ion flux. Understanding the gating mechanism of mechanosensitive channels is …

Piezo1 ion channels mediate the conversion of mechanical forces into electrical signals and
are critical for responsiveness to touch in metazoans. The apparent mechanical sensitivity of …

Merely touching the pancreas can lead to premature zymogen activation and pancreatitis
but the mechanism is not completely understood. Here we demonstrate that pancreatic …

Piezo1 is a member of the mechanosensitive piezo ion channel family, which transduces
various mechanical stimulations into electrochemical signals. Piezo1 is closely implicated in …

Prostate cancer is one of the most common types of cancer affecting men worldwide;
however, its etiology and pathological mechanisms remain poorly understood. Mechanical …