[HTML][HTML] DAMPs and NETs in sepsis
Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to
infection. Much has been focused on host response to pathogens mediated through the …
infection. Much has been focused on host response to pathogens mediated through the …
[HTML][HTML] Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity
KC Navegantes, R de Souza Gomes… - Journal of translational …, 2017 - Springer
Macrophages and neutrophils are key components involved in the regulation of numerous
chronic inflammatory diseases, infectious disorders, and especially certain autoimmune …
chronic inflammatory diseases, infectious disorders, and especially certain autoimmune …
Neutrophil dysregulation during sepsis: an overview and update
XF Shen, K Cao, J Jiang, WX Guan… - Journal of cellular and …, 2017 - Wiley Online Library
Sepsis remains a leading cause of death worldwide, despite advances in critical care, and
understanding of the pathophysiology and treatment strategies. No specific therapy or drugs …
understanding of the pathophysiology and treatment strategies. No specific therapy or drugs …
The role of the host—Neutrophil biology
ILC Chapple, J Hirschfeld, A Kantarci… - Periodontology …, 2023 - Wiley Online Library
Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with
lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial …
lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial …
[HTML][HTML] Role of neutrophil extracellular traps in health and disease pathophysiology: recent insights and advances
MM Islam, N Takeyama - International Journal of Molecular Sciences, 2023 - mdpi.com
Neutrophils are the principal trouper of the innate immune system. Activated neutrophils
undergo a noble cell death termed NETosis and release a mesh-like structure called …
undergo a noble cell death termed NETosis and release a mesh-like structure called …
[HTML][HTML] Targeting neutrophils in sepsis: from mechanism to translation
X Shen, K Cao, Y Zhao, J Du - Frontiers in pharmacology, 2021 - frontiersin.org
Sepsis is a life-threatening condition caused by a dysregulated host response to infection.
Although our understanding in the pathophysiological features of sepsis has increased …
Although our understanding in the pathophysiological features of sepsis has increased …
Deletion of Nlrp3 augments survival during polymicrobial sepsis by decreasing autophagy and enhancing phagocytosis
NLRP3 inflammasome is a critical player in innate immunity. Neutrophil recruitment to
tissues and effective neutrophil function are critical innate immune mechanisms for bacterial …
tissues and effective neutrophil function are critical innate immune mechanisms for bacterial …
[HTML][HTML] The lipid biology of sepsis
K Amunugama, DP Pike, DA Ford - Journal of Lipid Research, 2021 - ASBMB
Sepsis, defined as the dysregulated immune response to an infection leading to organ
dysfunction, is one of the leading causes of mortality around the globe. Despite the …
dysfunction, is one of the leading causes of mortality around the globe. Despite the …
[HTML][HTML] Neutrophil heterogeneity and its role in infectious complications after severe trauma
L Hesselink, R Spijkerman, KJP van Wessem… - World Journal of …, 2019 - Springer
Background Trauma leads to a complex inflammatory cascade that induces both immune
activation and a refractory immune state in parallel. Although both components are deemed …
activation and a refractory immune state in parallel. Although both components are deemed …
Calprotectin is superior to procalcitonin as a sepsis marker and predictor of 30-day mortality in intensive care patients
A Larsson, J Tydén, J Johansson… - … Journal of Clinical …, 2020 - Taylor & Francis
Sepsis is the most frequent cause of death in the intensive care unit (ICU). A rapid and
correct diagnosis and initiation of therapy is crucial for improving patient outcomes. The aim …
correct diagnosis and initiation of therapy is crucial for improving patient outcomes. The aim …