Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to
infection. Much has been focused on host response to pathogens mediated through the …

Macrophages and neutrophils are key components involved in the regulation of numerous
chronic inflammatory diseases, infectious disorders, and especially certain autoimmune …

Sepsis remains a leading cause of death worldwide, despite advances in critical care, and
understanding of the pathophysiology and treatment strategies. No specific therapy or drugs …

Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with
lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial …

Neutrophils are the principal trouper of the innate immune system. Activated neutrophils
undergo a noble cell death termed NETosis and release a mesh-like structure called …

Sepsis is a life-threatening condition caused by a dysregulated host response to infection.
Although our understanding in the pathophysiological features of sepsis has increased …

NLRP3 inflammasome is a critical player in innate immunity. Neutrophil recruitment to
tissues and effective neutrophil function are critical innate immune mechanisms for bacterial …

Sepsis, defined as the dysregulated immune response to an infection leading to organ
dysfunction, is one of the leading causes of mortality around the globe. Despite the …

Background Trauma leads to a complex inflammatory cascade that induces both immune
activation and a refractory immune state in parallel. Although both components are deemed …

Sepsis is the most frequent cause of death in the intensive care unit (ICU). A rapid and
correct diagnosis and initiation of therapy is crucial for improving patient outcomes. The aim …