Methylation of cytosines within the CpG dinucleotide by DNA methyltransferases is involved
in regulating transcription and chromatin structure, controlling the spread of parasitic …

DNA methylation is important in the control of gene transcription and chromatin structure.
The complexities of this process are just beginning to be elucidated in relationship to other …

The Snf2 family of helicase-related proteins includes the catalytic subunits of ATP-
dependent chromatin remodelling complexes found in all eukaryotes. These act to regulate …

Maintenance of a genome requires DNA repair integrated with chromatin remodeling. We
have analyzed six transcriptome data sets and one data set on translational regulation of …

Altering cytosine methylation by genetic means leads to a variety of developmental defects
in mice 1, plants 2, 3, 4, 5 and fungi 6, 7. Deregulation of cytosine methylation also has a …

Methylation patterns of the mammalian genome are thought to be crucial for development.
The precise mechanisms designating specific genomic loci for methylation are not known …

Imperfect maintenance of genome integrity has been postulated to be an important cause of
aging. Here we provide support for this hypothesis by demonstrating that the disruption of …

Deletion of Lsh perturbs DNA methylation patterns in mice yet it is unknown whether Lsh
plays a direct role in the methylation process. Two types of methylation pathways have been …

Abstract HELLS/LSH (Helicase, Lymphoid Specific) is a SNF2-like chromatin remodelling
protein involved in DNA methylation. Its loss-of-function in humans causes humoral …

Epigenetic regulation of transcriptional silencing is essential for normal development.
Despite its importance, in vivo systems for examining gene silencing at cellular resolution …