Visualizing the structure and dynamics of biomolecules is critical to understand biological
function, and requires methods to fluorescently label targets of interest in their cellular …

Macrophages perform a variety of different biological functions and are known for their
essential role in the immune response. In this context, a principal function is phagocytic …

Developing tissues form spatial patterns by establishing concentration gradients of diffusible
signaling proteins called morphogens. The bone morphogenetic protein (BMP) morphogen …

The self-labeling protein tags (SLPs) HaloTag7, SNAP-tag, and CLIP-tag allow the covalent
labeling of fusion proteins with synthetic molecules for applications in bioimaging and …

The functionalization of liposomes with monoclonal antibodies is a potential strategy to
increase the specificity of liposomes and reduce the side-effects associated with …

The microtubule-stabilizing chemotherapy drug paclitaxel (PTX) causes dose-limiting
chemotherapy-induced peripheral neuropathy (CIPN), which is often accompanied by pain …

Tools to image membrane tension in response to mechanical stimuli are badly needed in
mechanobiology. We have recently introduced mechanosensitive flipper probes to report …

Inflammation causes pain by shifting the balance of ionic currents in nociceptors toward
depolarization, leading to hyperexcitability. The ensemble of ion channels within the plasma …

Many G protein-coupled receptors (GPCRs) initiate a second phase of stimulatory
heterotrimeric G protein (Gs)-coupled cAMP signaling after endocytosis. The prevailing …

Selectively labeling cells with damaged membranes is needed not only for identifying dead
cells in culture, but also for imaging membrane barrier dysfunction in pathologies in vivo …