Sensory hair cells are mechanoreceptors of the auditory and vestibular systems and are
crucial for hearing and balance. In adult mammals, auditory hair cells are unable to …

Vestibular sensation is essential for gaze stabilization, balance, and perception of gravity.
The vestibular receptors in mammals, Type I and Type II hair cells, are located in five small …

Hearing loss is a widespread public health issue affecting hundreds of millions of people
worldwide. Hearing loss can be treated with cochlear implants or hearing aids but biological …

We developed a transgenic mouse to permit conditional and selective ablation of hair cells
in the adult mouse utricle by inserting the human diphtheria toxin receptor (DTR) gene into …

The capacity of adult mammals to regenerate sensory hair cells is not well defined. To
explore early steps in this process, we examined reactivation of a transiently expressed …

Deafness caused by the terminal loss of inner ear hair cells is one of the most common
sensory diseases. However, nonmammalian animals (eg, birds, amphibians, and fish) …

Atoh1 (also known as Math1, Hath1, and Cath1 in mouse, human, and chicken, respectively)
is a proneural basic helix–loop–helix (bHLH) transcription factor that is required in a variety …

Sensorineural hearing loss is most commonly caused by the death of hair cells in the organ
of Corti, and once lost, mammalian hair cells do not regenerate. In contrast, other vertebrates …

The mammalian cochlea loses its ability to regenerate new hair cells prior to the onset of
hearing. In contrast, the adult vestibular system can produce new hair cells in response to …

During development, Sox2 is indispensable for cell division and differentiation, yet its roles
in regenerating tissues are less clear. Here, we used combinations of transgenic mouse …