Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …

Cell therapy has been identified as an effective method to regenerate damaged tissue. Adult
stem cells, also known as somatic stem cells or resident stem cells, are a rare population of …

Background: Whether the adult mammalian heart harbors cardiac stem cells for
regeneration of cardiomyocytes is an important yet contentious topic in the field of …

Background Numerous studies from different labs around the world report human cardiac
progenitor cells (hCPCs) as having a role in myocardial repair upon ischemia/reperfusion …

Until a decade ago it was believed that the wall of adult blood vessels exclusively contains
terminally differentiated cell types. A paradigm shift was unavoidable since studies from …

Cardiovascular diseases have been closely linked to abnormal epigenetic regulation. In the
context of epigenetic regulation, BRG1, a pivotal SWI/SNF chromatin remodeling enzyme …

Populations of resident stem cells (SCs) are responsible for maintaining, repairing, and
regenerating adult tissues. In addition to having the capacity to generate all the differentiated …

The dermal Panniculus carnosus (PC) muscle is important for wound contraction in lower
mammals and represents an interesting model of muscle regeneration due to its high cell …

Oxidative stress-induced myocardial apoptosis and necrosis are critically involved in
ischemic infarction, and several sources of extracellular vesicles appear to be enriched in …

Background The inability of the adult mammalian heart to replace cells lost after severe
cardiac injury compromises organ function. Although the heart is one of the least …