Exercise mimetics: harnessing the therapeutic effects of physical activity

C Gubert, AJ Hannan - Nature Reviews Drug Discovery, 2021 - nature.com
Exercise mimetics are a proposed class of therapeutics that specifically mimic or enhance
the therapeutic effects of exercise. Increased physical activity has demonstrated positive …

Promoter DNA hypermethylation and paradoxical gene activation

J Smith, S Sen, RJ Weeks, MR Eccles, A Chatterjee - Trends in cancer, 2020 - cell.com
DNA methylation is a stable epigenetic modification that contributes to the spatiotemporal
regulation of gene expression. The manner in which DNA methylation contributes to …

Role of hypoxia inducible factor-1 in cancer stem cells

Q Zhang, Z Han, Y Zhu, J Chen… - Molecular Medicine …, 2021 - spandidos-publications.com
Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence,
metastasis, and chemo‑, radio‑and immuno‑resistance. Understanding the mechanism of …

In response to abiotic stress, DNA methylation confers epigenetic changes in plants

Z Akhter, Z Bi, K Ali, C Sun, S Fiaz, FU Haider, J Bai - Plants, 2021 - mdpi.com
Epigenetics involves the heritable changes in patterns of gene expression determined by
developmental and abiotic stresses, ie, drought, cold, salinity, trace metals, and heat. Gene …

Gene regulation of intracellular adhesion molecule-1 (ICAM-1): A molecule with multiple functions

M Singh, M Thakur, M Mishra, M Yadav, R Vibhuti… - Immunology letters, 2021 - Elsevier
Abstract Intracellular adhesion molecule 1 (ICAM-1) is one of the most extensively studied
inducible cell adhesion molecules which is responsible for several immune functions like T …

The role of DNA methylation in personalized medicine for immune-related diseases

MK Gupta, H Peng, Y Li, CJ Xu - Pharmacology & Therapeutics, 2023 - Elsevier
Epigenetics functions as a bridge between host genetic & environmental factors, aiding in
human health and diseases. Many immune-related diseases, including infectious and …

Epigenetic basis and targeting of cancer metastasis

R Banerjee, J Smith, MR Eccles, RJ Weeks… - Trends in Cancer, 2022 - cell.com
Despite the development of novel therapeutic approaches and improved clinical
management, survival from metastatic disease remains poor. Indeed, metastasis accounts …

Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis

J Lee, JH Song, JH Park, MY Chung, SH Lee… - … & Molecular Medicine, 2023 - nature.com
Dynamic alteration of DNA methylation leads to various human diseases, including
nonalcoholic fatty liver disease (NAFLD). Although C-Maf-inducing protein (Cmip) has been …

An epigenetic signature of advanced colorectal cancer metastasis

EJ Rodger, G Gimenez, P Ajithkumar, PA Stockwell… - IScience, 2023 - cell.com
Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. The
majority of CRC deaths are caused by tumor metastasis, even following treatment. There is …

DNA methylation in genetic and sporadic forms of neurodegeneration: lessons from Alzheimer's, related tauopathies and genetic tauopathies

G Zimmer-Bensch, H Zempel - Cells, 2021 - mdpi.com
Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer's
Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect …