Exercise mimetics: harnessing the therapeutic effects of physical activity
Exercise mimetics are a proposed class of therapeutics that specifically mimic or enhance
the therapeutic effects of exercise. Increased physical activity has demonstrated positive …
the therapeutic effects of exercise. Increased physical activity has demonstrated positive …
Promoter DNA hypermethylation and paradoxical gene activation
DNA methylation is a stable epigenetic modification that contributes to the spatiotemporal
regulation of gene expression. The manner in which DNA methylation contributes to …
regulation of gene expression. The manner in which DNA methylation contributes to …
Role of hypoxia inducible factor-1 in cancer stem cells
Q Zhang, Z Han, Y Zhu, J Chen… - Molecular Medicine …, 2021 - spandidos-publications.com
Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence,
metastasis, and chemo‑, radio‑and immuno‑resistance. Understanding the mechanism of …
metastasis, and chemo‑, radio‑and immuno‑resistance. Understanding the mechanism of …
In response to abiotic stress, DNA methylation confers epigenetic changes in plants
Epigenetics involves the heritable changes in patterns of gene expression determined by
developmental and abiotic stresses, ie, drought, cold, salinity, trace metals, and heat. Gene …
developmental and abiotic stresses, ie, drought, cold, salinity, trace metals, and heat. Gene …
Gene regulation of intracellular adhesion molecule-1 (ICAM-1): A molecule with multiple functions
Abstract Intracellular adhesion molecule 1 (ICAM-1) is one of the most extensively studied
inducible cell adhesion molecules which is responsible for several immune functions like T …
inducible cell adhesion molecules which is responsible for several immune functions like T …
The role of DNA methylation in personalized medicine for immune-related diseases
Epigenetics functions as a bridge between host genetic & environmental factors, aiding in
human health and diseases. Many immune-related diseases, including infectious and …
human health and diseases. Many immune-related diseases, including infectious and …
Epigenetic basis and targeting of cancer metastasis
Despite the development of novel therapeutic approaches and improved clinical
management, survival from metastatic disease remains poor. Indeed, metastasis accounts …
management, survival from metastatic disease remains poor. Indeed, metastasis accounts …
Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis
Dynamic alteration of DNA methylation leads to various human diseases, including
nonalcoholic fatty liver disease (NAFLD). Although C-Maf-inducing protein (Cmip) has been …
nonalcoholic fatty liver disease (NAFLD). Although C-Maf-inducing protein (Cmip) has been …
An epigenetic signature of advanced colorectal cancer metastasis
EJ Rodger, G Gimenez, P Ajithkumar, PA Stockwell… - IScience, 2023 - cell.com
Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. The
majority of CRC deaths are caused by tumor metastasis, even following treatment. There is …
majority of CRC deaths are caused by tumor metastasis, even following treatment. There is …
DNA methylation in genetic and sporadic forms of neurodegeneration: lessons from Alzheimer's, related tauopathies and genetic tauopathies
G Zimmer-Bensch, H Zempel - Cells, 2021 - mdpi.com
Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer's
Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect …
Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect …