Methods for the determination of binding constants by capillary electrophoresis
KL Rundlett, DW Armstrong - Electrophoresis, 2001 - Wiley Online Library
Apparent equilibrium constants for molecular association (eg, association constants, binding
constants, dissociation constants, partition coefficients) can be determined with a variety of …
constants, dissociation constants, partition coefficients) can be determined with a variety of …
Capillary electrophoresis frontal analysis: principles and applications for the study of drug‐plasma protein binding
J Østergaard, NHH Heegaard - Electrophoresis, 2003 - Wiley Online Library
Capillary electrophoresis is a well‐established technique for the study of noncovalent
interactions. Various approaches exist and capillary electrophoresis‐frontal analysis …
interactions. Various approaches exist and capillary electrophoresis‐frontal analysis …
Analysis of drug interactions with serum proteins and related binding agents by affinity capillary electrophoresis: A review
Biomolecules such as serum proteins can interact with drugs in the body and influence their
pharmaceutical effects. Specific and precise methods that analyze these interactions are …
pharmaceutical effects. Specific and precise methods that analyze these interactions are …
Development of affinity microcolumns for drug–protein binding studies in personalized medicine: interactions of sulfonylurea drugs with in vivo glycated human serum …
J Anguizola, KS Joseph, OS Barnaby… - Analytical …, 2013 - ACS Publications
This report used high-performance affinity microcolumns to examine the changes in binding
by sulfonylurea drugs to in vivo glycated HSA that had been isolated from individual patients …
by sulfonylurea drugs to in vivo glycated HSA that had been isolated from individual patients …
Physico-chemical characterization of liposomes and drug substance–liposome interactions in pharmaceutics using capillary electrophoresis and electrokinetic …
U Franzen, J Østergaard - Journal of chromatography A, 2012 - Elsevier
Liposomes are self-assembled phospholipid vesicles and have numerous research and
therapeutic applications. In the pharmaceutical and biomedical sciences liposomes find use …
therapeutic applications. In the pharmaceutical and biomedical sciences liposomes find use …
Impact of stereoselectivity on the pharmacokinetics and pharmacodynamics of antiarrhythmic drugs
Many antiarrhythmic drugs introduced into the market during the past three decades have a
chiral centre in their structure and are marketed as racemates. Most of these agents …
chiral centre in their structure and are marketed as racemates. Most of these agents …
Improvement of a capillary electrophoresis/frontal analysis (CE/FA) method for determining binding constants: discussion on relevant parameters
Drug–plasma protein interactions have a significant impact on both pharmacokinetics (ie,
absorption, distribution, metabolism, and excretion) and pharmacodynamics …
absorption, distribution, metabolism, and excretion) and pharmacodynamics …
Lipid vesicles in capillary electrophoretic techniques: Characterization of structural properties and associated membrane‐molecule interactions
RL Owen, JK Strasters, ED Breyer - Electrophoresis, 2005 - Wiley Online Library
This paper reviews the use of lipid vesicles as model membranes in capillary
electrophoresis (CE). The history and utility of CE in the characterization of microparticles is …
electrophoresis (CE). The history and utility of CE in the characterization of microparticles is …
Studies of metabolite–protein interactions: a review
R Matsuda, C Bi, J Anguizola, M Sobansky… - … of Chromatography B, 2014 - Elsevier
The study of metabolomics can provide valuable information about biochemical pathways
and processes at the molecular level. There have been many reports that have examined …
and processes at the molecular level. There have been many reports that have examined …