Side effects of statins: from pathophysiology and epidemiology to diagnostic and therapeutic implications

M Ruscica, N Ferri, M Banach, CR Sirtori… - Cardiovascular …, 2022 - academic.oup.com
Abstract Treatment with statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A
reductase, has proven beneficial preventive effects on cardiovascular events. However …

Effects of statins on mitochondrial pathways

H Mollazadeh, E Tavana, G Fanni, S Bo… - Journal of Cachexia …, 2021 - Wiley Online Library
Statins are a family of drugs that are used for treating hyperlipidaemia with a recognized
capacity to prevent cardiovascular disease events. They inhibit β‐hydroxy β‐methylglutaryl …

[HTML][HTML] PoLA/CFPiP/PCS/PSLD/PSD/PSH guidelines on diagnosis and therapy of lipid disorders in Poland 2021

M Banach, P Burchardt, K Chlebus… - Archives of Medical …, 2021 - ncbi.nlm.nih.gov
Moreover, over the last few years the approach to treatment of patients with a high
cardiovascular risk has totally changed from treatment aimed at a specific risk factor (ie …

Phase 2b randomized trial of the oral PCSK9 inhibitor MK-0616

CM Ballantyne, P Banka, G Mendez, R Garcia… - Journal of the American …, 2023 - jacc.org
Background MK-0616 is an oral macrocyclic peptide inhibitor of proprotein convertase
subtilisin/kexin type 9 (PCSK9) in development for the treatment of hypercholesterolemia …

Weight loss intervention adherence and factors promoting adherence: a meta-analysis

M Lemstra, Y Bird, C Nwankwo, M Rogers… - Patient preference and …, 2016 - Taylor & Francis
Background Adhering to weight loss interventions is difficult for many people. The majority of
those who are overweight or obese and attempt to lose weight are simply not successful …

Nonadherence with antipsychotic medication in schizophrenia: challenges and management strategies

PM Haddad, C Brain, J Scott - Patient related outcome measures, 2014 - Taylor & Francis
Nonadherence with medication occurs in all chronic medical disorders. It is a particular
challenge in schizophrenia due to the illness's association with social isolation, stigma, and …

[HTML][HTML] La adherencia al tratamiento en las enfermedades crónicas

LE Ramos Morales - Revista cubana de angiología y cirugía vascular, 2015 - scielo.sld.cu
Introducción: la falta de adherencia al tratamiento en el contexto de las enfermedades
crónicas es considerada como un grave problema de salud. Objetivo: examinar los …

[HTML][HTML] Bempedoic acid: for whom and when

M Ruscica, CR Sirtori, S Carugo, M Banach… - Current Atherosclerosis …, 2022 - Springer
Abstract Purpose of Review The aim of creating an orally active non-statin cholesterol-
lowering drug was achieved with bempedoic acid, a small linear molecule providing both a …

Effect of an siRNA therapeutic targeting PCSK9 on atherogenic lipoproteins: prespecified secondary end points in ORION 1

KK Ray, RM Stoekenbroek, D Kallend, LA Leiter… - Circulation, 2018 - Am Heart Assoc
Background: The ORION-1 trial (Trial to Evaluate the Effect of ALN-PCSSC Treatment on
Low Density Lipoprotein Cholesterol [LDL-C]) demonstrated that inclisiran, an siRNA …

Primary nonadherence to chronic disease medications: a meta-analysis

M Lemstra, C Nwankwo, Y Bird… - Patient preference and …, 2018 - Taylor & Francis
Background Medication nonadherence is a global problem that requires urgent attention.
Primary nonadherence occurs when a patient consults with a medical doctor, receives a …