Cancer is an extremely complex disease, typically caused by mutations in cancer-critical
genes. By delivering therapeutic nucleic acids (NAs) to patients, gene therapy offers the …

Among the new molecular tools available to scientists and engineers, some of the most
useful include fluorescently tagged biomolecules. Tools, such as green fluorescence protein …

We introduce a method, single-particle profiler, that provides single-particle information on
the content and biophysical properties of thousands of particles in the size range 5–200 nm …

Hybrid core–shell lipid–polycation–nucleic acid nanoparticles (LPNPs) provide unique
delivery strategies for nonviral gene therapeutics. Since LPNPs consist of multiple …

Liposomes can efficiently deliver messenger RNA (mRNA) into cells. When mRNA cocktails
encoding different proteins are needed, a considerable challenge is to efficiently deliver all …

Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
associated nuclease 9 (Cas9) gene-editing offers exciting new therapeutic possibilities for …

One of the main concerns in oligonucleotide-based therapeutics is achieving a successful
cell targeting while avoiding drug degradation and clearance. Nanoparticulated drug …

Hypothesis Modification of polyallylamine hydrochloride (PAH) with heterobifunctional low
molecular weight polyethylene glycol (PEG)(600 and 1395 Da), and subsequent attachment …

Cationic polymer-DNA complexes, or polyplexes, have been subject to intensive
investigation as potentially efficient non-viral systems for gene therapy. Yet the effects of …

There are more than two hundred fifty different types of cancers, that are diagnosed around
the world. Prostate cancer is one of the suspicious type of cancer spreading very fast around …