Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many
anticancer drugs require specificity of delivery to cancer cells, whilst sparing healthy tissue …

The hydrophilic nature of peptides and proteins renders them impermeable to cell
membranes. Thus, in order to successfully deliver peptide and protein-based therapeutics …

Hypoxia is a common feature of malignant tumors. There is an interactive connection
between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis …

Tumor hypoxia has been considered to be a potential therapeutic problem because it
renders solid tumors more resistant to sparsely ionizing radiation (IR) and chemotherapeutic …

In recent years, vast amounts of data on the mechanisms of neural de-and regeneration
have accumulated. However, only in disproportionally few cases has this led to efficient …

The direct intracellular delivery of proteins, or active peptide domains, has, until recently,
been difficult to achieve due primarily to the bioavailability barrier of the plasma membrane …

Owing to their unprecedented selectivity, specific activity and potential for 1000+ fold
amplification of signal, macromolecules, such as peptides, catalytic protein domains …

Protein transduction domains (PTDs) are small cationic peptides that can facilitate the
uptake of large, biologically active molecules into mammalian cells. Recent reports have …

Abstract Cell-penetrating peptide (CPP)-mediated intracellular drug delivery system, often
specifically termed as “the Trojan horse approach”, has become the “holy grail” in achieving …

RNAi-mediated silencing of specific genes is a promising strategy for gene therapy. To
utilize RNAi for therapy, an efficient and safe method for delivery of RNA into the cell cytosol …