The presence of cell and tissue barriers together with the low biomembrane permeability of
various therapeutics often hampers systemic drug distribution; thus, most of the available …

ABSTRACT Introduction: Cell penetrating peptides (CPPs) known as protein translocation
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …

The failure of proteins to penetrate mammalian cells or target tumor cells restricts their value
as therapeutic tools in a variety of diseases such as cancers. Recently, protein transduction …

The penetration of polar or badly soluble compounds through a cell membrane into live cells
requires mechanical support or chemical helpers. Cell‐penetrating peptides (CPPs) are very …

Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful
albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability …

The selective infiltration of cell membranes and tissue barriers often blocks the entry of most
active molecules. This natural defense mechanism prevents the invasion of exogenous …

Cell penetrating peptides (CPPs) have been extensively explored as molecular vectors
through covalent linkage to anticancer drugs to improve the drug's water solubility and to …

Introduction: Macromolecular therapeutics, including enzymes, transcription factors, siRNAs,
peptides and large synthetic molecules, can potentially be used to treat human diseases by …

Cardiovascular diseases (CVD) including acute myocardial infarction (AMI) rank first in
worldwide mortality and according to the World Health Organization (WHO), they will stay at …

Conjugation of anticancer drugs to hydrophilic peptides such as Tat is a widely adopted
strategy to improve the drug's solubility, cellular uptake, and potency against cancerous …